RESEARCH INTERESTS
Sleep Disorders
Sleep Apnea
Metabolic Dysfunction of Sleep Disorders

Dr. Herdegen directly supervises the outpatient sleep clinics at the University of Illinois which provides care for more than 1500 patients/year with the sleep laboratory performing 1000 sleep studies/year. In addition, Dr. Herdegen has participated in a number of clinical research trials involving treatment of insomnia, narcolepsy, and sleep-disordered breathing including residual sleepiness after effective treatment of sleep-disordered breathing. His current research activities include study of the metabolic consequences associated with sleep-disordered breathing and the effects of bariatric surgery on sleep-disordered breathing.

PROFESSIONAL BACKGROUND
1989-1990 Attending Physician and Medical Supervisor, Medical Residency Unit of the Cook County Jail, Chicago, Illinois

1993-2004 Assistant Professor of Medicine, Section of Pulmonary and Critical Care Medicine Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois

1998-2002 Medical Director, Sleep Disorder Service Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois

1998-2004 Co-Director, Sleep Medicine Training Program Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois

1998-2004 Assistant Director, Department of Respiratory Therapy, Rush University Medical Center, Chicago, Illinois

1998-Present Reviewer: Critical Care Medicine

1998-Present Voluntary Attending, Cook County Hospital, Chicago, Illinois

1999-2004 Director, Sleep Disorder Service Cook County Hospital, Chicago , Illinois

2001-Present Reviewer, Chest

2002-Present Adjunct Assistant Professor, College of Engineering Bioengineering, University of Illinois at Chicago, Chicago, Illinois

2004-Present Medical Director, UIC Sleep Science Center, University of Illinois
Medical Center, Chicago, Illinois

2005-Present Associate Professor of Clinical Medicine, University of Illinois at Chicago, Chicago, Illinois

REPRESENTATIVE PUBLICATIONS
Herdegen JJ, Bone RC. Inflammatory mediators in the critically ill. In: Intensive Care: Developments and Controversies. Webster NR, Bedenham A, eds. Bailliere's Clinical Anaesthesiology. Vol 6, Ch 8. W.B. Saunders. London 1991.

Herdegen JJ, Bone RC. Dyspnea of 2-weeks duration and left pleural effusion in a previously healthy 50-year-old woman. In: Pulmonary and Critical Care Pearls. Sahn SA, ed. Chest 1993;104:1264-1265.

Herdegen JJ, Casey LC. The role of tumor necrosis factor in infections: Pathophysiology and clinical implications. Infections In Medicine 1993;10:27-42.

Herdegen JJ, Bone RC. The role of anticholinergic therapy in obstructive airways disease. Gross NJ, ed. Franklin Scientific Publications, London 1994.

Herdegen JJ, Bone RC. Inflammatory mediators and the role of immunomodulation in sepsis. In: Pulmonary and Critical Care Medicine. Bone RC, Dantzker D, George R, Matthay R, Reynolds H, eds. Mosby-Year Book. Chicago 1994.

Herdegen JJ. Pulmonary Section Cases 11-1 to 11-12. In: Diagnostic strategies for Internal Medicine: A Case-Based Approach. Grodzin CJ, Schwartz SC, Bone RC, eds. Mosby-Year Book. Chicago 1996.

Herdegen JJ, Bone RCB. Immunomodulation in Sepsis: Lessons Learned. In: Pulmonary and Critical Care Medicine. Bone RC, Dantzker D, George R, Matthay R, Reynolds H, eds. Mosby-Year Book. Chicago 1996.

Herdegen JJ, Bone RC. Pulmonary manifestations of extrapulmonary infection. In: Infectious Diseases Teaching Atlas. Mandell GL, et. al. ed. Current Medicine 1996.

Herdegen JJ. Sleep-associated breathing disorders. In: Hospital Physician Pulmonary Disease Board Review Manual 1996.

Herrera P, Herdegen JJ. Infectious Complications of AIDS. In: Hospital Physician Pulmonary Review Board Review Manual 1996

Herdegen JJ, Herrera P. Tuberculosis: A case-based approach. In: Hospital Physician Pulmonary Disease Board Review Manual 1998.

Ferrell S, Herdegen JJ. Central sleep apnea In: Neurobase Arbor Publishing, San Diego 1999.

Herdegen JJ. Sleep disorders associated with cardiac disorders. In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2003.

Herdegen JJ. Central alveolar hypoventilation. In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2002, 2003.

Herdegen JJ. Sleep disorders associated with chronic lung disorders. In: Neurobase Arbor Publishing, San Diego 1999, 2000, 2001, 2002, 2003.

Herdegen JJ. Noninvasive positive pressure ventilatory support in patients with chronic respiratory failure. Hospital Physician Pulmonary Disease Board Review Manual 2000; Vol. 7, Part 4.

Stevens S, Herdegen JJ. Central sleep apnea In: Neurobase Arbor Publishing, San Diego 2000, 2001.

Herdegen JJ. Intensive care unit sleep disruption: Can the cycle be restored? Critical Care Medicine 2002;30:709-710.

Giri VV, Herdegen JJ. Sleep disorders associated with cardiac disorders. In: Neurobase Arbor Publishing, San Diego 2002.

Herdegen JJ. Treating syndrome X in minority populations: Begin with the treatment of obesity and hypertension. Ethnicity and Disease 2002;12:429-432.

Herdegen JJ. Chronic Disease and Sleep Architecture: Pharmacotherapeutic Considerations In: Sleep and Sleep Disorders: A Neuropharmacological Approach. Lader M, Cardinali DP, Pandi-Perumal SR, eds. Landes Bioscience Georgetown, TX 2004.

Herdegen JJ. Sleep Pharmacology Sleep Medicine Secrets Stevens, Dr ed. Hanley & Belfus, Inc. Philadelphia, PA 2004.

Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T. Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Int Med 2005;165:447-452.

Hassaballa HA, Tulaimat A, Herdegen JJ, Mokhlesi B. The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath 2005;9:176-180.

Mokhlesi B, Tulaimat A, Evans AT, Wang Y, Hassaballa HA, Itani A-A, Herdegen JJ, Stapanski EJ. Impact of adherence with positive airway pressure therapy on hypercapnia in obstructive sleep apnea. J Clin Sleep Med 2006;2:57-62.

Herdegen JJ. Inadequate sleep hygiene. In: Neurobase Arbor Publishing, San Diego 2007.

Joo MJ, Herdegen JJ. Sleep apnea in an urban public hospital: assessment of severity and treatment adherence. J Clin Sleep Med 2007;3:285-288.

Prasad B, Herdegen JJ. Sleep and quality of life in obesity. In: Sleep and Quality of Life in Medical Illnesses. Verster JC, Streiner D, Pandi-Perumal SR ed. (in press).

Kallwitz E, Herdegen J, Madura J, Jakate S, Cotler SJ. Liver enzymes and histology in obese patients with obstructive sleep apnea. J Clin Gastroenterology. (in press).