RESEARCH INTERESTS
Sleep Disorders: Impact of compromised cerebral blood flow and hemodynamics on cognitive function in obstructive sleep apnea.

Asthma: Clinical asthma care and trials; Gene-environment interaction in the expression of asthma using urban and rural communities in a developing country as a model.

Health Policy: Global health as well as health disparities and ethnic variability in the expression of obesity using asthma and sleep disorders as models.

PROFESSIONAL BACKGROUND
1980-1981 Internship, flexible in Medicine, Surgery, Pediatrics and Oby/Gyn at the University College Hospital, Ibadan, Nigeria

1981-1982 Medical Officer, National Sports Commission Medical Center, Lagos, Nigeria (National Youth Corps Service)

1982-1983 Medical Officer, Mount Sinai Hospital, Lagos, Nigeria

1984-1985 Internship in Medicine, Cook County Hospital, Chicago, Illinois

1985-1986 Resident in Medicine, Cook County Hospital, Chicago, Illinois

1986-1987 Chief Medical Resident, Cook County Hospital, Chicago, Illinois

1987-1988 Attending Physician, Michael Reese Hospital Medical Center, Chicago, Illinois

1988-1991 Post Doctoral Fellowship, Thoracic Diseases, Mayo Clinic, Rochester, Minnesota

1990-1991 Clinical Instructor in Medicine, Mayo Medical School, Rochester, Minnesota

1991-1997 Assistant Professor, Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois

1991-Present Attending Physician, University of Illinois Hospital, Chicago, Illinois

1991-Present Attending Physician, Westside VA Medical Center, Chicago, Illinois

1991-1993 Director, Respiratory Therapy, Westside VA Medical Center, Chicago, Illinois

1991-1993 Deputy Chief, Section of Respiratory and Critical Care Medicine, Westside VA Medical Center, Chicago, Illinois

1993-Present Director, Asthma Clinical Research, University of Illinois, Chicago, Chicago, Illinois

1995-1996 Physician Advisor, Utilization Management, University of Illinois at Chicago, Chicago, Illinois

1996-1999 Director, Respiratory Services,Vencor Hospital of Chicago, Chicago, Illinois

1996-2000 Director, Pulmonary Outpatient Services, University of Illinois at Chicago, Chicago, Illinois

1997-2007 Associate Professor (tenured), Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois

1999-2007 Director, Asthma Clinical Research Program (American Lung Association Supported), University of Illinois at Chicago, Chicago, Illinois

2000-2004 Medical Director, Center for Sleep and Ventilatory Disorders,
University of Illinois at Chicago, Chicago, Illinois

2003 Adjunct Faculty, College of Medicine, University of Ibadan, Ibadan, Nigeria

2005-Present Associate Director, Sleep Science Center, University of Illinois at Chicago, Chicago, Illinois

2005-Present Director, Clinical Research, Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois

2006-2007 Director, Pulmonary Function Laboratory, Jessie Brown Veteran Administration Medical Center, Chicago, Illinois

2007-Present Professor (tenured), Section of Pulmonary, Critical Care and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois

REPRESENTATIVE PUBLICATIONS
Olopade CO, Prakash UBS. Bronchoscopy in the critical care unit. Mayo Clin Proc 1989;64:1255-1263.

Olopade CO, Staats BA. Time course of recovery from "Frost Bitten Phrenics" following Coronary Artery Bypass Graft Surgery. Chest 1991;99:1112-1115.

Olopade CO, Viggiano RW, Beck KC, Staats BA. Exercise limitation and pulmonary rehabilitation in COPD. Mayo Clin Proc 1992;67:144-157.

Olopade CO, Crotty TB, Douglas WW, Colby TV, Sur S. Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil major basic protein. Mayo Clin Proc 1995;70:137-142.

Gao X-p, Suzuki H, Olopade CO, Rubinstein I. Short-term exposure to lipopolysaccharide is associated with microvascular contractile dysfunction in vivo. Life Sci 1995;56(15):1243-1249.

Gao X-p, Jaffe HA, Olopade CO, Rubinstein I. Stable VIP analogue Ro-24-9981, potentiates substance P-induced plasma exudation in hamster cheek pouch. J Appl Physio 1995;79(3):968-974.

Suzuki H, Gao X-p, Olopade CO, Jaffe HA, Pakhlevaniants S, Rubinstein I. Aqueous smokeless tobacco extract impairs endothelium-dependent vasodilation in the oral mucosa. J Appl Physio 1996;81(1):225-231.

Suzuki H, Gao X-p, Olopade CO, Rubinstein I. Neutral endopeptidase modulates VIP-induced vasodilatation in hamster cheek pouch vessels in situ. Am J Physio 1996;271:R393-R397.

Sekosan M, Zakkar M, Wenig B, Olopade CO, Rubinstein I. Inflammation is in the uvula mucosa of patients with obstructive sleep apnea. Laryngoscope 1996;106:1018-1020.

Gao X-p, Vishwanatha JK, Conlon JM, Olopade CO, Jaffe HA, Rubinstein I. Mechanisms of smokeless tobacco-induced buccal mucosa inflammation: role of bradykinin. J Immunol 1996;157:4624-4633.

Zakkar M, Sekosan M, Wenig B, Olopade CO, Rubinstein I. Immunoreactive neutral endopeptidase is decreased in uvula epithelium of patients with obstructive sleep apnea. Ann Otol Rhinol and Laryngol 1997;106:474-477.

Olopade CO, Alikakos Z, Abubaker J, Rubinstein I. Characteristics of predominantly non-white patients with frequent hospitalizations for acute asthma in Chicago. J Asthma 1997;34:243-248.

Olopade CO, M Zakkar, Swedler WI, Rubinstein I. Exhaled pentane levels in acute asthma. Chest 1997;111:862-865.

Olopade CO, Christon JA, Zakkar M, Hua C-w, Swedler WI, Scheff PA, Rubinstein I. Exhaled pentane and nitric oxide levels in patients with obstructive sleep apnea. Chest 1997;111:1500-1504.

Gao X-p, Suzuki H, Pakhlevaniants S, Olopade CO, Rubinstein I. Purified ACE attenuates smokeless tobacco induced macromolecular efflux from the oral mucosa. J Appl Physio 1997;83:74-81.

Olopade CO, Sekosan M, Schraufnagel D. Giant Cell Arteritis: An unusual cause of chronic cough and fever of unknown origin. Mayo Clin Proc 1997;72:1048-1050.

Gao X-p, Suzuki H, Olopade CO, Pakhlevaniants S, Rubinstein I. Angiotensin-converting enzyme and neutral endopeptidase modulate smokeless tobacco-induced increase in macromolecular efflux from the oral mucosa in vivo. J Lab Clin Med 1997;130:395-400.

Thomas AR, Chan L, Bauman, Olopade CO. Prolongation of QT interval due to cisapride-diltiazem interaction. Pharmacotherapy 1998;18(2):381-385.

Mutlu G, Daghestani A, Smith R, Olopade CO. Primary Extramedullary Plasmacytoma presenting as an obstructiing bronchial lesion. J Bronchol 2000;7:50-53.

Mutlu G, Chan L, Moonjelly E, Olopade CO. Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta-2 agonists containing edetate disodium. Mayo Clin Proc 2000;75(3):285-287.

The safety of inactivated Influenza Vaccine in adults and children with asthma. NEJM 2001;345:1529-1536. As authored by "The American Lung Association Asthma Clinical Research Centers (including CO Olopade)".

Chaer RA, Massad MG, Evans A, Olopade C, Varga J. Systemic Sclerosis complicated by diffuse alveolar hemorrhage. Med Sci Monit 2001;7(5):1013-1015.

See C, Olopade CO. An unusual cause of stridor and progressive shortness of breath. Chest 2005;128(3):1874-1877.

Olopade CO, Abubaker J, Yu J, Rubinstein I, Paul S. VIP Hydrolysis is increased in pregnant patients with asthma. J of Asthma 2006;43:429-432.

See QS, Mensah E, Olopade CO. Obesity, ethnicity and sleep disordered breathing. Medical and health policy implications. Clin Chest Med 2006;521-533.

Carley DW, Olopade CO, Ruigt GS, Radulovacki M. Mirtazapine in obstructive sleep apnea. Sleep 2007;30(1):35-41.

Falusi AG, Olopade OI, Olopade CO. Establishment of a standing ethics/institutional review board in a nigerian university: a blueprint for developing countries. J of Empirical Res on Human Res Ethics March 2007; 21-30.

Alternatives for step-down therapy for mild asthmatics well controlled on twice daily inhaled corticosteroid. As authored by "The American Lung Association Asthma Clinical Research Centers (including CO Olopade)". NEJM March 2007.

Olopade CO, Gupta BA, Mensah E, Huo D, Piecchietti D, Gratton E, Michalos A. Non-invasive determination of brain tissue oxygenation during sleep in obstructive sleep apnea: a near-infrared spectroscopic approach. SLEEP (in press).