Research

Patricia Hershberger, PhD, APRN Funded Projects

Preimplantation Genetic Diagnosis: Couples’ Decision Making at the Genetic and Reproductive Interface

Funding Source: Internal Research Support Program

Dates: 06/01/08– 05/31/09

Co-Investigators: Karen Kavanaugh

Abstract: Advances in human genetics and assisted reproduction have expanded dramatically and includes the innovative option of Preimplantation Genetic Diagnosis (PGD). This form of genetic screening circumvents conventional forms of prenatal diagnosis by identifying genetic disorders or chromosomal rearrangements prior to the establishment of pregnancy. Couples where one or both partners are carriers of genetic disorders may benefit from using PGD because they avoid the difficult decision of whether or not to terminate a pregnancy after receiving an unfavorable prenatal diagnosis. However, there are multiple disadvantages and far reaching considerations. Despite these implications, little is known about the decision making processes of couples surrounding PGD use or how best to access this dispersed population and obtain key information about their decision making process. The purpose of this pilot study is to refine recruitment and data collection measures in preparation for a larger R03 study. For this pilot study, recruitment of six couples will proceed through three approaches: an infertility center, a national newsletter and Internet web sites. Couples, consisting of a male and female dyad, will be interviewed independently from their partner. In-depth, open-ended interviews will be completed via telephone. The PI will record multiple recruitment data points into a detailed Reflexive Journal. Descriptive statistics and content analysis will guide the analysis. The findings will serve to refine both recruitment approaches and the interview guide and will strengthen the resubmission of an NIH proposal, if needed, or facilitate the implementation and completion of the study if an NIH award is received.