1. Smither, R. K., Knapp, G. S., and Westbrook, E. M. (1990). High intensity x-ray source using liquid gallium target. U.S. Patent 4,953,191, DOE Case S-66,027.
2. Collart, F. R., Huberman, E., Joachimiak, A., Zhang, R.-G., and Westbrook, E. M. (1999). Use of the crystal structure of bacterial IMP dehydrogenase to design inhibitors of bacterial growth. U.S. Patent applied for. DOE Case S-90, 563.

On Going Research Support:

1 R01 RR16334-01 Edwin M. Westbrook (PI) 03/15/02 – 03/31/05
NCRR
A CCD Crystallographic X-ray Detector with Lens Optics
This grant supports development of a new type of X-ray diffraction detector in which the CCD is coupled to the converting phosphor plate by a lens instead of a fiber-optic taper. There is no overlap of this project with the proposed project.
Role: Principal Investigator

1 R01 RR16230-01 Edwin M. Westbrook (PI) 03/15/02 – 03/31/05
NCRR
3DX: A Micromachined Silicon Crystallographic X-ray Detector
This grant supports development of a radically new type of X-ray diffraction detector in which X rays are captured directly in a silicon wafer. The detection wafer in this system is micro-machined to have a pixel array. The electronic signal is passed through bump bonds to a readout ASIC chip and subsequently to a computer. There is no overlap of this project with the proposed project.
Role: Principal Investigator

01-16615 Edwin M. Westbrook (PI) 06/01/02 – 05/31/05
NSF, Instrumentation and Instrument Development
Development of a Very Large Area Detector for Protein Crystallography
This grant supports development of a very large CCD area detector for protein crystallography. It will be used at the new MBC beamline. There is no overlap of this project with the proposed project.
Role: Principal Investigator

Beamline Construction Project Philip Matsumura(PI) 01/01/00 – 09/30/02
Molecular Biology Consortium
Construction of the ALS Beamline 4.2.2
This project is to build a beamline for the Molecular Biology Consortium, at the Advanced Light Source, that will be used for macromolecular crystallography. It is this beamline that we propose to automate as the central task of the proposed project. There is no overlap of this project with the proposed project.
Role: Project Manager and Consortium Director

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Selected Publications:

1. Stanton, M., Phillips, W. C., O'Mara, D., Naday, I., and Westbrook, E. M. (1993). Area detector design II: application to a modular CCD-based detector for x-ray crystallography. Nucl. Instrum. and Meth. A325, 558-567.
2. Getzoff, E. D., Jones, K. W., McRee, D., Moffat, K., Ng, K., Rivers, M. L., Schildkamp, W., Singer, P. T., Spanne, P., Sweet, R. M., Teng, T.-Y., and Westbrook, E. M. (1993). Laue diffraction protein crystallography at the National Synchrotron Light Source. Nucl. Instrum. and Meth. B79, 249-255.
3. Phillips, W. C., Stanton, M., O'Mara, D., Naday, I., and Westbrook, E. M. (1993). Modular CCD detectors for x-ray crystallography. Proc. S.P.I.E. 1900, 53-58.
4. Naday, I., Westbrook, E. M., Westbrook, M. L., Travis, D. J., Stanton, M., Phillips, W. C., and Xie, J. (1994). Characterization and data collection on a direct-coupled CCD x-ray detector. Nucl. Instrum. and Meth. A348, 635-640.
5. Zhang, R. G., Maulik, P. R., Westbrook, E. M., Reed, R. A., Scott, D. L., Otwinowski, Z., Westbrook, M. L., and Shipley, G. G. (1995). 2.3 Å crystal structure of cholera toxin B-subunit pentamer: "choleragenoid." J. Molec. Biol. 251, 550-562.
6. Zhang, R. G., ,Scott, D. L., Westbrook, M. L., Nance, S., Spanger, B. D., and Westbrook, E. M. (1995). The three-dimensional crystal structure of cholera toxin. J. Molec. Biol. 251, 563-573.
7. Ross, S. W., Naday, I., Kanyo, M., Westbrook, M. L., Westbrook, E. M., Phillips, W. C., Stanton, M. J., and Street, R. A. (1995). Amorphous silicon area detectors for protein crystallography. Proc. S.P.I.E. Sympos. 2415, 189-203.
8. Sanishvili, R., Volz, K. W., Westbrook, E. M., and Margoliash, E. (1995). The low ionic strength crystal structure of horse cytochrome c at 2.1 Å resolution. Comparison with its high ionic strength counterpart and possible new type of g-turns. Structure 3, 707-716.
9. Scott, D. L., Zhang, R.-G., and Westbrook, E. M. (1996). The Cholera Family of enterotoxins. in “Protein Toxin Structure”, Parker, M. W. editor. R. G. Landes Company, Austin, TX, pp. 123-146.
10. Westbrook, E. M. and Naday, I. (1997) CCD Area Detectors. Methods in Enzymology 276, Sweet, R. M. and Carter, C., editors, Academic Press, Orlando, pp 244-268.
11. Lima, C. D., D’Amico, K. L., Klein, M. G.., Naday, I., Rosenbaum, G., Westbrook, E. M., and Hendrickson, W. A. (1997). MAD Analysis of FHIT, a putative human tumor suppressor from the HIT protein family. Structure 5, 763-774.
12. Rosenbaum, G. & Westbrook, E. M. (1997). Miniaturized Kappa goniometer for macromolecular crystallography. Amer. Inst. Physics Conf. Proc. 417, E. Fontes, editor. American Institute of Physics, Ithaca, NY.
13. Westbrook, E. M. & Rosenbaum, G. (1997). The Structural Biology Center at the APS: an integrated user facility for macromolecular crystallography. Amer. Inst. Physics Conf. Proc. 417, E. Fontes, editor. American Institute of Physics, Ithaca, NY.
14. Zhang, R.-G., Evans, G., Rotella, F., Westbrook, E. M., Beno, D., Huberman, E., Joachimiak, A., & Collart, F. R., and (1999). Characteristics and crystal structure of bacterial inosine-5’-monophosphate dehydrogenase. Biochemistry 38, 4691-4700.
15. Zhang, R.-G., Evans, G., Rotella, F. J., Westbrook, E. M., Huberman, E., Joachimiak, A., and Collart, F. R. (1999). Differential signatures of bacterial and mammalian IMP dehydrogenase enzymes. Current Medicinal Chem. 6, 537-543.
16. Westbrook, E. M. (1999). Performance characteristics needed for protein crystal diffraction x-ray detectors. Proc. S.P.I.E. 3774, 2-16.
17. Naday, I., Sanishvili, R., Joachimiak, A., and Westbrook, E. M. (1999). Operational experience of a large-area X-ray camera for protein crystallography. Proc. S.P.I.E. 3774, 66-73.
18. Westbrook, E. M. (2001). Crystal density measurements. in International Tables for Macromolecular Crystallography, Volume F, edited by Rossmann, M. G. and Arnold, E., Kluker Academic Publishers, Dordrecht, The Netherlands, pp. 117-123.
19. Campos, A., Zhang, R.G., Matsumura, P., and Westbrook, E. M. (2001). The 1.8 Å crystal structure of flagellar transcriptional activator protein FlhD. Molec. Microbiol. 39, 567-580.
20. Wang, S.-Y., Matsumura, P., & Westbrook, E. M. (2001). Crystallization and preliminary X-ray crystallographic analysis of FlhD/FlhC complex from E. coli. Acta Crystallogr. D57, 734-736.