Meeting Schedule 

The scientific sessions will begin on the afternoon of Sunday June 2nd promptly at 1pm. Attendees can pick up their registration materials starting on Sunday morning at the registration desk in the hotel. The desk will be staffed throughout the meeting.

We have a very full schedule and it is essential that speakers keep to their allocated time limit.  Speakers will use PowerPoint for their presentations. We would ask that the Sunday speakers help us out by getting their talks to us as early as possible on Sunday. 

We have two poster sessions. The first poster session will consist of posters from submitted abstracts pertaining to the scientific sessions I to IV. The second poster session will consist of posters from submitted abstracts pertaining to the scientific sessions V to X. We will contact all poster presenters with more details by e-mail. Posters can be a maximum of 4 ft x 4 ft (122 cm x 122 cm) in size.

Meeting materials will be distributed in the morning. For your convenience we have a block of hotel rooms available for Saturday to Wednesday nights. See the hotel information page for details. Please reserve your rooms now to guarantee the special room rate we have negotiated. 

In addition, please register now if you have not already done so. It essential that we know the number of attendees so that we can plan accordingly. 

Sunday June 2nd (Afternoon and Evening)

1 pm. Opening and Welcome: Peter Gettins (University of Illinois at Chicago)

Session I. Serpin evolution, phylogenetics, and genomics (Chair: Gary Silverman, Harvard University)

1.10-1.30  Gary Silverman, Session Overview

1.30-1.50  James Whisstock (Monash University), "From whence they came and onward - serpins in eukaryotic (and prokaryotic!) organisms"

1.50-2.10  Jean-Marc Reichhart (University of Strasbourg), "The Drosophila immune system: Control by serpins"

Poster Talks I.1 and I.2

2.10-2.25  Stephen Pak (Harvard University), "Serpins in C. elegans"

2.25-2.40  Diana van Gent (University of Nottingham), "Identification of core promoter elements in serpins"

2.40-3.00  Break

Session II. Serpin-receptor and serpin-ligand interactions (Chair: Cynthia Peterson, University of Tennessee)

3.00-3.20  Cynthia Peterson, Session Overview

3.20-3.40  Dudley Strickland (American Red Cross), "LRP and serpin-proteinase complexes" 

3.40-4.00  Peter Andreasen (Aarhus University), "Interactions of serpins and serine proteases with receptors of the LDLR family"

Poster Talks II.1 and II.2 

4.00-4.15  Aiwu Zhou (University of Cambridge), "2.3 Å structure reveals PAI-1/ vitronectin interaction"

4.15-4.30  James Irving (Monash University), "The influence of DNA binding on the conformation of the nuclear serpin MENT"

5.30-7.30 Poster Session I (Poster 1-66. Posters should be displayed as early as possible to avoid delays in presentation) and Opening Night Reception 

Monday June 3rd (Morning, Afternoon and Evening)

8.00-9.00 Continental Breakfast

Session III. Mechanism and regulation of function (Chair: Elizabeth Goldsmith, University of Texas Southwestern, Dallas)

9.00-9.20 Elizabeth Goldsmith, Session Overview

9.20-9.40  Myeong-Hee Yu, (Korea Institute of Science and Technology), "Native strain of alpha-1-antitrypsin and serpin protein folding"

9.40-10.00  Michael Plotnick (University of Pennsylvania), "Insights into the structure of serpin-protease complexes from the analysis of the mechanism of complex breakdown"

Poster Talks III.1 and III.2

10.00-10.15  James Irving (Monash University), "A structural and biophysical study of a thermostable serpin from the bacterium Thermobifida fusca"

10.15-10.30  Norman Schechter (University of Pennsylvania), "Mechanism of human chymase inhibition by serpins"

10.30-11.00 Break

11.00-11.20  Jim Huntington (Cambridge University), "'Heparin cofactor II and the regulatory advantage of the serpin mechanism"

11.20-11.40  Peter Gettins (University of Illinois at Chicago). "Helix F plays an active critical role in the serpin mechanism"

Poster Talks III.3 and III.4

11.40-11.55  Grant Blouse (Henry Ford Hospital), " Mutation of the highly conserved hinge tryptophan in the breach region governs the serpin inhibitory mechanism of PAI-1"

11.55-12.10  Yolanda Fortenberry (University of North Carolina-Chapel Hill), "Molecular description of the thrombin-heparin cofactor II (HCII) inhibition reaction"

12.10-2.00 Lunch 

Session IV. Coagulation, fibrinolysis and vascular biology (Chair: Susan Bock, University of Utah)

2.00-2.20  Susan Bock, Session Overview

2.20-2.40  Doug Vaughan (Vanderbilt University), "PAI-1, arteriosclerosis and coronary thrombosis: Insights from genetically modified mice"

2.40-3.00  Tetsuhito Kojima (Nagoya University School of Health Sciences), "Antithrombin deficient mice"

Poster Talks IV.1 and IV.2

3.00-3.15  Alvin Davis (Harvard Medical School), "C1 inhibitor deficiency in the mouse results in increased vascular permeability"

3.15-3.30  Ray Rezaie (St. Louis University), "Basic residues of the 70-80 loop are involved in the heparin-dependent regulation of activated protein C by PCI"

3.30-3.50  Julie Chao (Medical University of South Carolina), " Kallistatin: A New Angiogenesis Inhibitor"

Poster Talks IV.3 and IV.4

3.50-4.05  Daniel Schuster (University of Giessen, Germany), "Antithrombin prevents proinflammatory activation via NFkB and MAPK signaling pathways"

4.05-4.20  B. de Taeye (K.U. Leuven, Belgium), "Importance of the mobility of the P' region for conformational and functional changes in PAI-1" 

4.30-7.00 Poster Session II (Posters 67-128. Beverages and snacks will be provided.  Posters should be displayed throughout the day, if possible)

On Monday night you are free to explore Chicago. Chicago has a vibrant nightlife and restaurant scene for you to enjoy. The links page has more information.

Tuesday June 4th (Morning Only)

7.30-8.30  Continental breakfast

Session V. Serpins in cancer and angiogenesis (Chair: Phil Bird, Monash University)

8.30-8.50  Phil Bird, Session Overview

8.50-9.10  Mary Hendrix (University of Iowa), "Novel tyrosine phosphorylation of the serpin maspin in normal mammary epithelia and transfected breast cancer cell lines"

9.10-9.30  Miljan Simonovic (University of Illinois at Chicago), 'The structure of PEDF"

Poster Talks V.1-V.4

9.30-9.45  Won-Jin Lu (National Health Research Institutes, Taiwan), "Association of serpin B13 SNPs and genetic-cancer susceptibility"

9.45-10.00  Chatri Ngamkitidachakul (Medical College of Wisconsin), "The RSL of maspin is required for induction of cell-matrix adhesion: conversion of ovalbumin to a maspin-like molecule"

10.00-10.15  Dan Lawrence (American Red Cross), "PAI-1 is a potent regulator of tumor growth and angiogenesis"

10.15-10.30  Grant Darnell (Queensland Institute of Medical Research), "Plasminogen activator inhibitor-2 has an intracellular activity as a retinoblastoma binding protein"

10.30-11.00  Break

Session VI. Serpins as therapeutic agents (Chair: David Lomas, Cambridge University)

11.00-11.20  David Lomas, Session Overview

11.20-11.40  Maurice Petitou (Sanofi), "Stimulating serpins with synthetic tailor-made oligosaccharides. A new generation of antithrombotics"

11.40-12.00  Ken Brigham (Emory University), "Lipoplex delivery of an alpha-1 antitrypsin (AAT) transgene to the lungs: organ targeted antiprotease therapy"

Poster Talks VI.1 and VI.2 

12.00-12.15  Alex Lucas (University of Western Ontario), "Viral serpin mediated regulation  of transplant vasculopathy"

12.15-12.30  Erik Dufour (Universite de Sherbrooke, Canada). "Inhibitory properties of SERPINA1 and SERPINA3 variants towards the pro-protein converting enzyme furin" 

On Tuesday afternoon and evening you are free to explore Chicago. If anyone wants to go fishing on Lake Michigan contact Martin Hansen (mah@mbio.aau.dk) as he is chartering a fishing boat for the afternoon.

Wednesday June 5th (Morning, Afternoon and Evening)

7.00-8.00  Continental Breakfast

Session VII. Serpins in reproduction and development (Chair: Ariane de Agostini, University of Geneva)

8.00-8.20 Ariane de Agostini, Session Overview

8.20-8.40  Margarethe Geiger (University of Vienna), "Infertility in male PCI-knockout mice: Role of proteases and retinoids"

8.40-9.00  Peter Hansen (University of Florida), "Physiological and biochemical properties of the uterine serpins, a class of progesterone-induced endometrial secretory proteins" 

Poster Talks VII.1 and VII.2

9.00-9.15  Marguerite Buzza (Monash University, Australia), " Expression of the granzyme B inhibitor PI-9 in non-lymphoid and reproductive tissues"

9.15-9.30  T. Hayashi (Mie University, Japan), "Characterization of human protein C inhibitor gene transgenic mouse"

9.30-10.00  Break

VIII. Serpins in infectious disease and inflammation (Chair: Harvey Rubin, University of Pennsylvania)

10.00-10.20 Harvey Rubin, Session Overview

10.20-10.40  Giorgio Fassina (Xeptagen SpA, Italy): "SCCA variants and liver diseases"

10.40-11.00  Richard Moyer (University of Florida), "The viral serpins: Additional functional complexities suggested by interactions with other proteins"

Poster Talks VIII.1 and VIII.2

11.00-11.15  David Shapiro (University of Illinois-Urbana), "Induction of PI-9 regulates production of pro-inflammatory cytokines"

11.15-11.30  Eileen Remold-O'Donnell (Harvard Medical School), "rMNEI (SERPINB1) protects pulmonary SP-A, a microbial opsonin, from degradation by protease in cystic fibrosis airways"

11.30-1.00  Lunch

IX. Serpins in neurological function and disease (Chair: Dan Lawrence, American Red Cross)

1.00-1.20  Dan Lawrence, Session Overview

1.20-1.40  Lars Nilsson (University of S. Florida), "Amyloid formation and cognitive decline depends on the serpin alpha-1-antichymotrypsin and apolipoprotein E in Alzheimer's disease transgenic mice"

1.40-2.00  Denis Monard (Friedrich Miescher Institute, Basel), "Expression of Protease nexin-1 and in vivo neuronal functions"

Poster Talks IX.1 and IX.2

2.00-2.15  R. Davis (SUNY Syracuse, New York), "Neuroserpin mutations determine inclusion-body formation and secerity of myoclonus epilepsy and dementia"

2.15-2.30  Damian Crowther (Cambridge University), "Nucleation of alpha1-antichymotrypsin polymerisation: a mechansim for the deposition of alpha1-antichymotrypsin in the amyloid plaques of Alzheimer's disease"

2.30-3.00  Break

X. New and enigmatic serpins (Chair: Penny Stein, Cambridge University)

3.00-3.20  Penny Stein, Session overview

3.20-3.40  Geoff Pickering (Robards Research Institute), "Hsp47 and vascular restructuring"

3.40-4.00  Alain Kummer (University of Lausanne), "The human serpin Protease Inhibitor 8: in search for a physiological function"

Poster Talks X.1 and X.2

4.00-4.15  Tim Dafforn (Cambridge University), "Heat shock protein 47 (Hsp47) and its implications for collagen biosynthesis"

4.15-4.30  Sergei Grigoryev (Penn State University), "On the role of the reactive center loop in intracellular localization of a nuclear serpin MENT":

4.30-4.50  Closing Remarks: Robin Carrell (Cambridge University)

6.30-7.00  Assemble for bus transportation to Shedd Aquarium

7.00-11.00  Closing  Reception and Banquet at Shedd Aquarium (Guest tickets are available for this event)