UIC/NIH Center for Botanical Dietary Supplement Research in Women's Health

College of Pharmacy
masthead

Research Publications

2014 (4)

Bisphenol A (BPA) Found in Humans and Water in Three Geographic Regions with Distinctly Different Levels of Economic Development.
Karalius VP, Harbison JE, Plange-Rhule J, van Breemen RB, Li G, Huang K, Durazo-Arvizu RA, Mora N, Dugas LR, Vail L, Tuchman NC, Forrester T, Luke A
Environ Health Insights. 2014;8:1-3.

Universal quantitative NMR analysis of complex natural samples.
Simmler C, Napolitano JG, McAlpine JB, Chen SN, Pauli GF.
Curr Opin Biotechnol.
2014;25c:51-9.

Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.
Yuan Y, Qiu X, Nikolic D, Chen SN, Huang K, Li G, Pauli GF, van Breemen RB Eur
J Pharm Sci. 2014;53:55-61.

2013

Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.
Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton.
JLMol Nutr Food Res. 2013;57(6):1055-66.

Lipidated steroid saponins from Dioscorea villosa (wild yam)
Dong SH, Cai G, Napolitano JG, Nikolic D, Lankin DC, McAlpine JB, van Breemen RB, Soejarto DD, Pauli GF, Chen SN.
Fitoterapia. 2013;91:113-24

Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms.
Drogos LL, Rubin LH, Geller SE, Banuvar S, Shulman LP, Maki PM.
Menopause. 2013;20(12):1236-42

Botanical modulation of menopausal symptoms: mechanisms of action?
Hajirahimkhan A, Dietz BM, Bolton JL.
Planta Med. 2013;79(7):538-53

Evaluation of estrogenic activity of licorice species in comparison with Hops used in botanicals for menopausal symptoms.
Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolic D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL.
PLoS One. 2013;8(7)

Quantitative analysis of phytosterols in edible oils using APCI liquid chromatography-tandem mass spectrometry. Lipids.
Mo S, Dong L, Hurst WJ, van Breemen RB.
2013;48(9):949-56.

Analytical methods for quantitation of prenylated flavonoids from hops
Nikolic D, van Breemen RB.
Curr Anal Chem. 2013;9(1):71-85.

Absolute configuration of naturally occurring glabridin.
Simmler C, Fronczek FR, Pauli GF, Santarsiero BD.
Acta Crystallogr C. 2013;69(Pt 11):1212-6.

Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay
Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF.
J Agric Food Chem. 2013;61(9):2146-57. Epub. 2013/02/23.

Phytochemistry and biological properties of glabridin.
Simmler C, Pauli GF, Chen SN
Fitoterapia .2013;90:160-84

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective alpha4beta2-nAChR partial agonist and promising antidepressant
Yuan Y, Yu LF, Qiu X, Kozikowski AP, van Breemen RB.
J Chromatogr B Analyt Technol Biomed Life Sci. 2013;912:38-42

Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages.
Zhao G, Yu R, Deng J, Zhao Q, Li Y, Joo M, van Breemen RB, Christman JW, Xiao L.
Mol Pharmacol.
2013;83(1):167-78.

2012

Diarylheptanoids from Dioscorea villosa (Wild Yam)
Dong SH, Nikolic D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen SN.
J Nat Prod. 2012;75(12):2168-77.

Dereplication, residual complexity, and rational naming: the case of the Actaea triterpenes.
Qiu F, Imai A, McAlpine JB, Lank in DC, Burton I, Karakach T, Farnsworth NR, Chen SN, Pauli GF.
J Nat Prod. 2012;75(3):432-43.

Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Snelten CS, Dietz B, Bolton JL
Drug Discov Today Dis Mech.2012;9(1)

Biological characterization of non-steroidal progestins from botanicals used for women's health.
Toh MF, Sohn J, Chen SN, Yao P, Bolton JL, Burdette JE.
Steroids.
2012;77(7):765-73.

Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum.
Yuan Y, Qiu X, Nikolic D, Dahl JH, van Breemen RB
J AOAC Int. 2012;95(6):1744-9.

2011

Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) van Breemen RB, Tao Y, Li W
Fitoterapia. 2011. 82:38-43

Modification of Keap1 cysteine residues by sulforaphane
Hu C. Eggler AL, Mesecar AD, van Breemen RB
Chemical Research in Toxicology24(4), pp 515-521, 2011.

Phytoconstituents from Vitex agnus-castus fruits.
Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, Fong HH, Farnsworth NR, Pauli GF.
Fitoterapia. 2011 Jun;82(4):528-33. Epub 2010 Dec 13.

Modification of keap1 cysteine residues by sulforaphane.
Hu C, Eggler AL, Mesecar AD, van Breemen RB.
Chem Res Toxicol . 2011 Apr 18;24(4):515-21. Epub 2011 Mar 10.

Discussion of a well-designed clinical trial which did not demonstrate effectiveness: UIC center for botanical dietary supplements research study of black cohosh and red clover.
Shulman LP, Banuvar S, Fong HH, Farnsworth NR.
Fitoterapia. 2011 Jan;82(1):88-91. Epub 2010 Oct 27.

Biological reactive intermediates (BRIs) formed from botanical dietary supplements.
Dietz BM, Bolton JL.
Chem Biol Interact . 2011 Jun 30;192(1-2):72-80. Epub 2010 Oct 21. Review.

Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.
Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB.
Anal Chem . 2011 Feb 1;83(3):1048-52. Epub 2010 Dec 30. Erratum in: Anal Chem. 2011 Jun 1;83(11):4325. van Breemen, Richard R [corrected to van Breemen, Richard B].

Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).
van Breemen RB, Tao Y, Li W.
Fitoterapia . 2011 Jan;82(1):38-43. Epub 2010 Sep 15.

Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry.
Cao H, Yu R, Tao Y, Nikolic D, van Breemen RB.
J Pharm Biomed Anal . 2011 Jan 5;54(1):230-5. Epub 2010 Aug 13.

Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.
Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ.
Biochem Pharmacol. 2011 Jan 1;81(1):170-7. Epub 2010 Sep 18.

2010

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB.
Pharmacol Res . 2010 Jun;61(6):519-24. Epub 2010 Feb 24.

Disposition of hop prenylflavonoids in human breast tissue.
Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H.
Mol Nutr Food Res . 2010 Jul;54 Suppl 2:S284-94.

Lung cancer and hormone replacement therapy.
Barton M, Meyer MR, Bolton JL, Prossnitz ER.
Lancet . 2010 Jan 9;375(9709):117-8; author reply 118-9. No abstract available.

Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.
Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM.
Cancer Prev Res (Phila) . 2010 Feb;3(2):221-32. Epub 2010 Jan 12.

Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.
van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen SN, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, Geller SE, Farnsworth NR.
Clin Pharmacol Ther . 2010 Feb;87(2):219-25. Epub 2009 Dec 23.

2009

Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.
Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR.
Menopause . 2009 Nov-Dec;16(6):1156-66.

Effects of botanicals and combined hormone therapy on cognition in postmenopausal women.
Maki PM, Rubin LH, Fornelli D, Drogos L, Banuvar S, Shulman LP, Geller SE.
Menopause . 2009 Nov-Dec;16(6):1167-77.

Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women's Health: Black cohosh from the field to the clinic.
Farnsworth NR, Mahady GB.
Pharm Biol . 2009 Aug 1;47(8):755-760.

Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).
Gödecke T, Lankin DC, Nikolic D, Chen SN, van Breemen RB, Farnsworth NR, Pauli GF.
J Nat Prod . 2009 Mar 27;72(3):433-7.

Dynamic residual complexity of natural products by qHNMR: solution stability of desmethylxanthohumol.
Chen SN, Lankin DC, Chadwick LR, Jaki BU, Pauli GF.
Planta Med . 2009 Jun;75(7):757-62. Epub 2009 Jan 14.

Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF.
Phytochem Anal . 2009 Mar;20(2):120-33.

2008

Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.
Chem Res Toxicol . 2008 Oct;21(10):1939-48.Epub 2008 Sep 23.

Countercurrent separation of natural products.
Pauli GF, Pro SM, Friesen JB.
J Nat Prod . 2008 Aug;71(8):1489-508. Epub 2008 Jul 31. Review.

Objective hot flashes are negatively related to verbal memory performance in midlife women.
Maki PM, Drogos LL, Rubin LH, Banuvar S, Shulman LP, Geller SE.
Menopause . 2008 Sep-Oct;15(5):848-56.

Statistical scoring procedures applicable to laboratory performance evaluation.
Hedayat, A. S.; Su, Guoqin; Streets, W. Elane
J. Statist. Plann.Inference 138 (2008), no. 11, 3336–3349, 62P12 (62-07)

Locally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models.
Fang, X.; Hedayat, A. S.
Ann. Statist . 36 (2008), no. 1, 428–444, 62K05

Surveillance strategies for detecting changepoint in incidence rate based on exponentially weighted moving average methods.
Dong, Yuping; Hedayat, A. S.; Sinha, B. K.
J. Amer. Statist. Assoc . 103 (2008), no. 482, 843–853

Crossover designs based on type I orthogonal arrays for a self and simple mixed carryover effects model with correlated errors.
Hedayat, A. S.; Yan, Zhiwu
J. Statist. Plann. Inference 138 (2008), no. 7, 2201–2213.

Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers.
Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM.
Am J Clin Nutr . 2008 Feb;87(2):476S-80S. Review.

In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL.
J Agric Food Chem . 2008 Dec 24;56(24):11718-26.

Dynamic nature of the ligustilide complex.
Schinkovitz A, Pro SM, Main M, Chen SN, Jaki BU, Lankin DC, Pauli GF.
J Nat Prod . 2008 Sep;71(9):1604-11. Epub 2008 Sep 10.

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.
Chem Biol Interact . 2008 Oct 22;176(1):30-9. Epub 2008 Jun 20.

Anti-TB polyynes from the roots of Angelica sinensis.
Deng S, Wang Y, Inui T, Chen SN, Farnsworth NR, Cho S, Franzblau SG, Pauli GF.
Phytother Res . 2008 Jul;22(7):878-82.

An experimental implementation of chemical subtraction.
Chen SN, Turner A, Jaki BU, Nikolic D, van Breemen RB, Friesen JB, Pauli GF.
J Pharm Biomed Anal . 2008 Mar 13;46(4):692-8. Epub 2007 Dec 17.

2007

Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells.
Pang Y, Nikolic D, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB.
Mol Nutr Food Res . 2007 Jul;51(7):872-9.

Sites of alkylation of human Keap1 by natural chemoprevention agents.
Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB.
J Am Soc Mass Spectrom . 2007 Dec;18(12):2226-32. Epub 2007 Oct 2.

Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.
Eggler AL, Luo Y, van Breemen RB, Mesecar AD.
Chem Res Toxicol . 2007 Dec;20(12):1878-84. Epub 2007 Oct 13. Erratum in: Chem Res Toxicol. 2008 Feb;21(2):556.

Tools for constructing optimal two-level factorial designs for a linear model containing main effects and one two-factor interaction.
Hedayat, A. S.; Pesotan, H.
J. Statist. Plann. Inference 137 (2007), no. 4, 1452–1463

A unified approach for assessing agreement for continuous and categorical data.
Lin, Lawrence; Hedayat, A. S.; Wu, Wenting
J. Statist. Plann. Inference 137 (2007), no. 4, 1452–1463

Botanical dietary supplements gone bad.
Dietz B, Bolton JL.
Chem Res Toxicol . 2007 Apr;20(4):586-90. Epub 2007 Mar 16. No abstract available.

Secondary metabolites from Andrographis paniculata.
Li W, Xu X, Zhang H, Ma C, Fong H, van Breemen R, Fitzloff J.
Chem Pharm Bull (Tokyo) . 2007 Mar;55(3):455-8.

Chlorination diversifies Cimicifuga racemosa triterpene glycosides.
Chen SN, Lankin DC, Nikolic D, Fabricant DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF.
J Nat Prod . 2007 Jun;70(6):1016-23. Epub 2007 Jun 8.

The role of quality assurance and standardization in the safety of botanical dietary supplements.
van Breemen RB, Fong HH, Farnsworth NR.
Chem Res Toxicol . 2007 Apr;20(4):577-82. Epub 2007 Mar 16. Review. No abstract available.

A routine experimental protocol for qHNMR illustrated with Taxol.
Pauli GF, Jaki BU, Lankin DC.
J Nat Prod . 2007 Apr;70(4):589-95. Epub 2007 Feb 14.

Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon).
Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF.
J Nat Prod. 2007 Feb;70(2):253-8 Epub 2007 Feb 2.

2006

Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor.
Rhyu MR, Lu J, Webster DE, Fabricant DS, Farnsworth NR, Wang ZJ.
J Agric Food Chem . 2006 Dec 27;54(26):9852-7.

Contemporary alternatives to plant estrogens for menopause.
Geller SE, Studee L.
Maturitas . 2006 Nov 1;55 Suppl 1:S3-13. Epub 2006 Aug 1. Review.

In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.).
Nikolic D, Li Y, Chadwick LR, van Breemen RB.
Pharm Res . 2006 May;23(5):864-72. Epub 2006 May 16.

Optimal and efficient crossover designs when subject effects are random.
Hedayat, A. S.; Stufken, John; Yang, Min
J. Amer. Statist. Assoc . 101 (2006), no. 475, 1031–1038

Efficient crossover designs for comparing test treatments with a control treatment.
Hedayat, A. S.; Yang, Min
Discrete Math . 306 (2006), no. 23, 3112–3124

Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review.
Booth NL, Piersen CE, Banuvar S, Geller SE, Shulman LP, Farnsworth NR.
Menopause . 2006 Mar-Apr;13(2):251-64. Review.

Optimal designs in stability studies.
Hedayat, A. S.; Yan, Xu; Lin, Lawrence
J. Biopharm. Statist . 16 (2006), no. 1, 35–59

Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF.
J Nat Prod . 2006 Apr;69(4):536-41.

Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB.
Drug Metab Dispos . 2006 Jul;34(7):1152-9. Epub 2006 Apr 12.

The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.
Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR.
J Altern Complement Med . 2006 Mar;12(2):133-9.

Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.
Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR.
J Agric Food Chem . 2006 Feb 22;54(4):1277-82.

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties.
Chadwick LR, Pauli GF, Farnsworth NR.
Phytomedicine . 2006 Jan;13(1-2):119-31. Epub 2005 Jul 1. Review.

Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products.
He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, Roller M, Zheng Q.
J Chromatogr A . 2006 Apr 21;1112(1-2):241-54. Epub 2006 Mar 2.

2005

Inhibition of uropathogenic Escherichia coli by cranberry juice: a new antiadherence assay.
Turner A, Chen SN, Joike MK, Pendland SL, Pauli GF, Farnsworth NR.
J Agric Food Chem . 2005 Nov 16;53(23):8940-7.

Caco-2 cell permeability assays to measure drug absorption.
van Breemen RB, Li Y.
Expert Opin Drug Metab Toxicol . 2005 Aug;1(2):175-85. Review.

Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.
Cheng X, van Breemen RB.
Anal Chem . 2005 Nov 1;77(21):7012-5.

Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB.
Anal Chem . 2005 Oct 1;77(19):6407-14.

Optimal and efficient crossover designs for comparing test treatments with a control treatment.
Hedayat, A. S.; Yang, Min
Ann. Statist . 33 (2005), no. 2, 915–943.

Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.
Fabricant DS, Nikolic D, Lankin DC, Chen SN, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF.
J Nat Prod . 2005 Aug;68(8):1266-70.

Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL.
Chem Res Toxicol . 2005 Aug;18(8):1296-305.

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD.
Proc Natl Acad Sci U S A . 2005 Jul 19;102(29):10070-5. Epub 2005 Jul 8

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
Dietz BM, Mahady GB, Pauli GF, Farnsworth NR.
Brain Res Mol Brain Res . 2005 Aug 18;138(2):191-7.

Is there clinical evidence supporting the use of botanical dietary supplements in children?
Hrastinger A, Dietz B, Bauer R, Sagraves R, Mahady G.
J Pediatr . 2005 Mar;146(3):311-7. Review. No abstract available.

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.
Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB.
J Am Soc Mass Spectrom . 2005 Feb;16(2):271-9.

Quantitative 1H NMR: development and potential of a method for natural products analysis.
Pauli GF, Jaki BU, Lankin DC.
J Nat Prod . 2005 Jan;68(1):133-49. Review.

Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL.
J Agric Food Chem . 2005 Aug 10;53(16):6246-53.

Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba.
Sun Y, Li W, Fitzloff JF, van Breemen RB.
J Mass Spectrom . 2005 Mar;40(3):373-9.

Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.
Nikolic D, Li Y, Chadwick LR, Pauli GF, van Breemen RB.
J Mass Spectrom . 2005 Mar;40(3):289-99.

Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa.
Chen SN, Fabricant DS, Pauli GF, Fong HH, Farnsworth NR.
Nat Prod Res . 2005 Apr;19(3):287-90.

Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa.
Chen SN, Fabricant DS, Pauli GF, Fong HH, Farnsworth NR.
Nat Prod Res . 2005 Apr;19(3):287-90.

Knowledge, attitudes, and behaviors of healthcare providers for botanical and dietary supplement use for postmenopausal health.
Geller SE, Studee L, Chandra G.
Menopause . 2005 Jan-Feb;12(1):49-55.

2004

Estrogens and congeners from spent hops (Humulus lupulus).
Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF.
J Nat Prod . 2004 Dec;67(12):2024-32.

Confusion regarding anticoagulant coumarins in dietary supplements.
Booth NL, Nikolic D, van Breemen RB, Geller SE, Banuvar S, Shulman LP, Farnsworth NR.
Clin Pharmacol Ther . 2004 Dec;76(6):511-6. No abstract available.

Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry.
Mariappan SV, Cheng X, van Breemen RB, Silks LA, Gupta G.
Anal Biochem . 2004 Nov 15;334(2):216-26.

In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent.
Li Y, Grubjesic S, Nikolic D, Zhu D, Kosmeder JW, Moriarty RM, Pezzuto JM, Van Breemen RB.
Xenobiotica . 2004 Jun;34(6):535-47.

Optimal and efficient designs for 2-parameter nonlinear models.
Hedayat, A. S.; Zhong, J.; Nie, L.
J. Statist. Plann. Inference 124 (2004), no. 1, 205–217

Universal optimality for selected crossover designs.
Hedayat, A. S.; Yang, Min
J. Amer. Statist. Assoc . 99 (2004), no. 466, 461–466

New metabolic pathways for flavanones catalyzed by rat liver microsomes.
Nikolic D, van Breemen RB.
Drug Metab Dispos . 2004 Apr;32(4):387-97.

Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.
Nikolic D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB.
Drug Metab Dispos . 2004 Feb;32(2):272-9.

2003

Phytoestrogens in botanical dietary supplements: implications for cancer.
Piersen CE.
Integr Cancer Ther . 2003 Jun;2(2):120-38. Review.

Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL.
J Agric Food Chem . 2003 Sep 10;51(19):5661-70.

Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.
Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB.
Comb Chem High Throughput Screen . 2003 Dec;6(8):757-67. Review.

Resveratrol in raw and baked blueberries and bilberries.
Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB.
J Agric Food Chem . 2003 Sep 24;51(20):5867-70.

Universal optimality of balanced uniform crossover designs
Hedayat, A. S.; Yang, Min
Ann. Statist . 31 (2003), no. 3, 978–983.

Toward optimal health: the experts discuss the use of botanicals by women. Interview by Jody Godfrey Meisler.
Geller SE, Kronenberg F.
J Womens Health (Larchmt) . 2003 Nov;12(9):847-52

Adding more observations to saturated D-optimal resolution III two-level factorial designs.
Hedayat, A. S.; Zhu, Haiyuan
J. Combin. Des . 11 (2003), no. 1, 51–77.

Optimal and Efficient Crossover Designs Under Different Assumptions About the Carryover Effects
Hedayat AS, Stufken J.
J Biopharm Stat . 2003 Aug;13(3):519-28.

Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL.
J Agric Food Chem . 2003 Sep 10;51(19):5661-70

In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).
Johnson BM, van Breemen RB.
Chem Res Toxicol . 2003 Jul;16(7):838-46

Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL.
Chem Res Toxicol . 2003 Jun;16(6):741-9.

Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
Johnson BM, Qiu SX, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB.
Chem Res Toxicol . 2003 Jun;16(6):733-40.

Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.
Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH.
J Nat Prod . 2003 Feb;66(2):263-8.

Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.
Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB.
Rapid Commun Mass Spectrom . 2003;17(4):307-13.

p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products.
Li W, Sun Y, Joseph J, Fitzloff JF, Fong HH, van Breemen RB.
J Agric Food Chem . 2003 Jan 15;51(2):524-9.

Is black cohosh estrogenic?
Mahady GB.
Nutr Rev . 2003 May;61(5 Pt 1):183-6. Review.

Botanical dietary supplement use in peri- and postmenopausal women.
Mahady GB, Parrot J, Lee C, Yun GS, Dan A.
Menopause . 2003 Jan-Feb;10(1):65-72.

2002

Integration of herbal medicine into modern medical practices: issues and prospects.
Fong HH.
Integr Cancer Ther . 2002 Sep;1(3):287-93; discussion 293. Review.

Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature.
Mahady GB.
J Cardiovasc Nurs . 2002 Jul;16(4):21-32.

Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL.
J Agric Food Chem . 2002 Nov 20;50(24):7022-8.

Statistical methods in assessing agreement: models, issues, and tools.
Hedayat, A. S.; Sinha, Bikas; Yang, Min.
J. Amer. Statist. Assoc . 97 (2002), no. 457, 257–270.

Optimimum designs for estimating EDp based on raw optical density data.
Hedayat, A. S.; Yan, Bo; Pezzuto, John M.
J. Statist. Plann. Inference 104 (2002), no. 1, 161–174

Repeated measurements designs for a model with self and simple mixed carryover effects. Experimental design and related combinatorics.
Afsarinejad, K.; Hedayat, A. S.
J. Statist. Plann. Inference 106 (2002), no. 1-2, 449–459

Cimiracemosides I-P, new 9,19-cyclolanostane triterpene glycosides from Cimicifuga racemosa.
Chen SN, Fabricant DS, Lu ZZ, Fong HH, Farnsworth NR.
J Nat Prod . 2002 Oct;65(10):1391-7.

Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry.
Li W, Sun Y, Fitzloff JF, van Breemen RB.
Chem Res Toxicol . 2002 Sep;15(9):1174-8.

Cimiracemates A-D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa.
Chen SN, Fabricant DS, Lu ZZ, Zhang H, Fong HH, Farnsworth NR.
Phytochemistry . 2002 Oct;61(4):409-13.

Applications of pulsed ultrafiltration-mass spectrometry.
Johnson BM, Nikolic D, van Breemen RB.
Mass Spectrom Rev . 2002 Mar-Apr;21(2):76-86. Review.

Evaluation of commercial Ginkgo biloba dietary supplements for the presence of colchicine by high-performance liquid chromatography.
Li W, Fitzloff JF, Farnsworth NR, Fong HH.
Phytomedicine . 2002 Jul;9(5):442-6.

Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.
Chen SN, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR.
J Nat Prod . 2002 Apr;65(4):601-5.

Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.
Geun Shin Y, Bolton JL, van Breemen RB.
Comb Chem High Throughput Screen . 2002 Feb;5(1):59-64

2001

Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.
Constantinou AI, Lantvit D, Hawthorne M, Xu X, van Breemen RB, Pezzuto JM.
Nutr Cancer . 2001;41(1-2):75-81.

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.
J Agric Food Chem . 2001 May;49(5):2472-9.

Analysis and screening of combinatorial libraries using mass spectrometry.
Shin YG, van Breemen RB.
Biopharm Drug Dispos . 2001 Oct-Nov;22(7-8):353-72. Review.

Ginkgo Biloba: A Review of Quality, Safety, and Efficacy.
Gail B. Mahady
.Nutrition in Clinical Care , 2001, 4: 140–147.

An introduction to the ginseng evaluation program
Hall, T.; Lu, Z.-Z.; Yat, P.: Fitzloff, J. F.; Arnason, J. T; Awang, D. V. C.; Fong, H. H.; Blumenthal, M.;
HerbalGram. 2001, 57, 27-30.

Evaluation of consistency of standardized Asian ginseng products in the ginseng evaluation program.
Hall, T.; Lu, Z.-Z.; Yat, P.: Fitzloff, J. F.; Arnason, J. T; Awang, D. V. C.; Fong, H. H.; Blumenthal, M.;
HerbalGram. 2001, 57, 31-45. 2001

Global harmonization of herbal health claims.
Mahady GB.
J Nutr. 2001 Mar ;131(3s):1120S-3S.

Goldenseal (Hydrastis canadensis): Is There Enough Scientific Evidence to Support Safety and Efficacy?
Gail B. Mahady, Lucas R. Chadwick PhD
Nutrition in Clinical Care , 4: 243–249. 2001

Echinacea: Recommendations for its Use in Prophylaxis and Treatment of Respiratory Tract Infections.
Gail B. Mahady, Dima M. Qato, Charlotte Gyllenhaa, Luke Chadwick, Harry H.S.Fong
Nutrition in Clinical Care , 4: 199–208

Screening botanical extracts for quinoid metabolites.
Johnson BM, Bolton JL, van Breemen RB.
Chem Res Toxicol . 2001 Nov;14(11):1546-51.

2000

Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng).
Li W, Gu C, Zhang H, Awang DV, Fitzloff JF, Fong HH, van Breemen RB.
Anal Chem . 2000 Nov 1;72(21):5417-22.

Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.
Nikolic D, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB.
Anal Chem . 2000 Aug 15;72(16):3853-9.

Ginsengs:a review of safety and efficacy Farnsworth
Gail B. Mahady,Charlotte Gyllenhaal, Harry H.S. Fong, Norman R. Farnsworth PhD
Nutrition in Clinical Care Volume 3, Issue 2, pages 90–101, March/April 2000