Department of Biopharmaceutical Sciences

College of Pharmacy

Zain Paroo, Ph.D.

Zain Paroo, Ph.D.

Assistant Professor, Pharmacology

Contact Information
University of Illinois Medical Center
900 S. Ashland Ave
MBRB 3220, MC 870


Senior Post-Doctoral Fellow, Biochemistry, Southwestern Medical Center.

Post-Doctoral Fellow, Pharmacology, Southwestern Medical Center.

Ph.D., Faculty of Health Sciences, The University of Western Ontario.

Research Interests

Micro-RNA (miRNA)

Small-interfering RNA (siRNA)

Protein Biochemistry

RNA technologies and therapeutics

Publications (2007-2012)

Liu Q, Paroo Z. Dicer’s cut and switch. Science. 328: 314-315, 2010. DOI

Liu Q, Paroo Z. Biochemical principles of small RNA pathways. Annu Rev Biochem. 79, 2010.

Yoda M, Kawamata T, Paroo Z, Ye X, Liu Q, Tomari Y. ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol. 17: 17-23, 2010.

Paroo Z, Ye X, Chen S, Liu Q. Phosphorylation of the human micro-RNA-generating complex mediates MAPK/Erk signaling. Cell. 139: 112-122, 2009.

Paroo Z, Pertsemlidis A. Micro-RNAs mature with help from cancer biology. Genome Biol. 10: 310, 2009.

Shan G, Li Y, Zhang J, Li W, Szulwach K, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan A, Shi Z, Liu Q, Wahlestedt C, He C, Jin P. A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol. 26: 933-940, 2008.

Ye X, Paroo Z, Liu Q. Functional anatomy of the Drosophila microRNA-generating enzyme. J Biol Chem. 282: 28373-8, 2007.

Paroo Z, Liu Q, Wang X. Biochemical mechanisms of the RNA-induced silencing complex. Cell Res. 17:187-194, 2007.