Department of Biopharmaceutical Sciences

College of Pharmacy

Zaijie Jim Wang, Ph.D.

Zaijie Jim Wang, Ph.D.

Associate Professor, Pharmacology and Pharmaceutics

Contact Information
833 South Wood Street
3320 MBRB, MC 865
Chicago, IL 60612-7231
Office: (312) 355-1429
Fax: (312) 996-0098
Lab Website

Publications (2005-2009)
G Protein-Coupled Receptor; Signal Transduction, Phosphorylation, and Trafficking

Chen Y, Luo F, Yang C, Kirkmire C, Wang ZJ. Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice. J Pharmacol Exp Ther. 2009 May 28.

Luo F, Yang C, Chen Y, Shukla P, Tang L, Wang LX, Wang ZJ. Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinaseII. J Pharmacol Exp Ther. 2008 Apr;325(1):267-75. Epub 2008 Jan 4. DOI

Tang L, Chen, Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea (IBTU), a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. J Pharmacol Exp Ther. 2007 May;321(2):791-8. Epub 2007 Feb 20. DOI

Tang L, Shukla PK, Wang ZJ. Disruption of acute opioid dependence by antisense oligodeoxynucleotides targeting neurogranin. Brain Res. 2007 Apr 27;1143:78-82. Epub 2007 Jan 25. DOI

Tang L, Shukla PK, Wang LX, Wang ZJ. Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca2+/calmodulin-dependent protein kinase II. J Pharmacol Exp Ther. 2006;317:1-9. DOI

Shukla PK, Tang L, Wang ZJ. Phosphorylation of neurogranin, protein kinase C, and Ca(2+)/calmodulin dependent protein kinase II in opioid tolerance and dependence. Neurosci Lett. 2006;404(3):266-9. DOI

Tang L, Shukla PK, Wang ZJ. Attenuation of opioid tolerance by antisense oligodeoxynucleotides targeting neurogranin. Eur J Pharmacol Rapid Comm. 2006;542(1-3):106-7S. DOI

Bhalla S, Ciaccio N Wang ZJ, Gulati A. Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells. Exp Biol Med. 2006;231(6):1152-6. DOI

Wang ZJ, Wang LX. Phosphorylation--A molecular switch in opioid tolerance (Invited review) Life Sci. 2006 Sep 27;79(18):1681-91. Epub 2006 Jun 2. DOI

Tang L, Shukla PK, Wang ZJ. Trifluoperazine, an orally available clinically used drug, disrupts opioid antinociceptive tolerance. Neurosci Lett. 2006 Apr 10-17;397(1-2):1-4. Epub 2005 Dec 27. DOI

Lu J, Jeon E, Lee BS, Onyuksel H, Wang ZJ. Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes. J Control Release, 2006;110(3):505-513. DOI

Gardell LR, Ibrahim M, Wang R, Wang ZJ, Ossipov MH, Malan TP, Porreca F, Lai J. Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Neurosci. 2004;123:43-52. DOI