William T. Beck, Ph.D.
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Department Head Professor of Pharmacology and Molecular Genetics Contact Information 833 South Wood Street 335 Pharm, MC 865 Chicago, IL 60612-7231 Office: (312) 996-0888 Fax: (312) 996-0098 Email: wtbeck@uic.edu |
Education
Ph.D. - George Washington University - 1971
Research Interests
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Molecular pharmacology and genetics of anticancer drug action and tumor cell drug resistance (Related Publications) |
Molecular mechanisms of regulation of genes associated with multidrug resistance in cancer (Related Publications) |
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Action of and tumor cell resistance to inhibitors of the DNA topoisomerases (Related Publications) |
Role of splice variants in anticancer drug responsiveness (Related Publications) |
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Post-translational modifications of proteins (Related Publications) |
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Shen F, Bailey BJ, Chu S, Bence AK, Xue X, Erickson P, Safa AR, Beck WT, Erickson LC, Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by PSC833 in Multidrug Resistant Human Cancer Cells, J Pharmacol Exp Ther. 2009 May 7. DOI
Wu F, Zhu S, Ding Y, Beck WT, Mo YY, MicroRNA-mediated regulation of Ubc9 expression in cancer cells, Clin Cancer Res. 2009 Mar 1;15(5):1550-7. Epub 2009 Feb 17. DOI
Shen F, Chu S, Bence AK, Bailey B, Xue X, Erickson PA, Montrose MH, Beck WT, Erickson LC. Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J Pharmacol Exp Ther. 2008 Jan;324(1):95-102. Epub 2007 Oct 18. DOI
Wu F, Chiocca S, Beck WT, Mo YY. Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol Cancer Ther. 2007;6:1823-30. DOI
He X, Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene. 2007;26:4961-68. DOI
Beck WT, Ablordeppey SY, Elmquist WF, Galt KA, Malone DC, Mount JK, Miller KW. Impact of the NIH roadmap on the future of graduate education in colleges/schools of pharmacy. Am J Pharm Educ. 2005;69(S18):1-14.
Mirski SE, Sparks KE, Friedrich B, Kohler M, Mo YY, Beck WT, Cole SP. Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells. Exp Cell Res. 2007 Feb 1;313(3):627-37. Epub 2006 Nov 10. DOI
Kamalakaran S, Radhakrishnan SK, Beck WT. Identification of estrogen-responsive genes using a genome-wide analysis of promoter elements for transcription factor binding sites. J Biol Chem. 2005;280(22):21491-7. Epub 2005 Mar 24. DOI
Mo YY, Yu Y, Theodosiou E, Rachel Ee PL, Beck WT. A role for Ubc9 in tumorigenesis. Oncogene. 2005 Apr 14;24(16):2677-83. DOI