William T. Beck, Ph.D.
UIC Distinguished Professor
Professor, Pharmacology and Molecular Genetics
833 South Wood Street
335 Pharm, MC 865
Chicago, IL 60612-7231
Office: (312) 996-0888
Fax: (312) 996-0098
Ph.D. - George Washington University - 1971
|Molecular pharmacology and genetics of anticancer drug action and tumor cell drug resistance
|Molecular mechanisms of regulation of genes associated with multidrug resistance in cancer |
|Action of and tumor cell resistance to inhibitors of the DNA topoisomerases
|Role of splice variants in anticancer drug responsiveness|
|Post-translational modifications of proteins
Arslan AD, He X, Wang M, Rumschlag-Booms E, Rong L, Beck WT. A High-Throughput Assay to Identify Small-Molecule Modulators of Alternative Pre-mRNA Splicing. J Biomol Screen. 2013 Feb; 18(2):180-90
Cho S, Lu M, He X, Ee PL, Bhat U, Schneider E, Miele L, Beck WT.
Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proc Natl Acad Sci USA. 2011 Dec 20; 108(51):20778-83.
Das SG, Srinivasan B, Hermanson DL, Bleeker NP, Doshi JM, Tang R, Beck WT, Xing C. Structure-Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and Its Analogues. J Med Chem. 2011 Aug 25; 54(16):5937-48.
Natarajan K, Xie Y, Nakanishi T, Beck WT, Bauer KS, Ross DD. Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine. Biochim Biophys Acta. 2011 Jul; 1809(7):295-305.
Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT. Novel regulation of NF-YB by miR-485-3p affects expression of DNA topoisomerase II and drug responsiveness. Mol Pharmacol. 2011 Apr; 79(4):735-41.
He X, Arslan AD, Pool MD, Ho TT, Darcy KM, Coon JS, Beck WT. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. Oncogene. 2011 Jan 20;30(3):356-65.
Shen F, Bailey BJ, Chu S, Bence AK, Xue X, Erickson P, Safa AR, Beck WT, Erickson LC, Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by PSC833 in Multidrug Resistant Human Cancer Cells, J Pharmacol Exp Ther. 2009 May 7. DOI
Wu F, Zhu S, Ding Y, Beck WT, Mo YY, MicroRNA-mediated regulation of Ubc9 expression in cancer cells, Clin Cancer Res. 2009 Mar 1;15(5):1550-7. Epub 2009 Feb 17. DOI
Shen F, Chu S, Bence AK, Bailey B, Xue X, Erickson PA, Montrose MH, Beck WT, Erickson LC. Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J Pharmacol Exp Ther. 2008 Jan;324(1):95-102. Epub 2007 Oct 18. DOI
Wu F, Chiocca S, Beck WT, Mo YY. Gam1-associated alterations of drug responsiveness through activation of apoptosis. Mol Cancer Ther. 2007;6:1823-30. DOI
He X, Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT. Knockdown of polypyrimidine tract-binding protein (PTB) suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene. 2007;26:4961-68. Cited in Science Daily