Department of Biopharmaceutical Sciences

College of Pharmacy

Seungpyo Hong, Ph.D.

Seungpyo Hong, Ph.D.

Associate Professor, Pharmaceutics and Bioengineering

Contact Information
833 South Wood Street
355 PHARM, MC 865
Chicago, IL 60612-7231
Office: (312) 413-8294
Fax: (312) 996-0098
Lab Website


Postdoctoral - Massachusetts Institute of Technology - 2008
Ph.D. - University of Michigan - 2006
M.S. - Hanyang University/Korea Institute of Science and Technology - 2001
B.S. - Hanyang University - 1999

Research Interests

Targeted Drug Delivery Using Polymeric Nanomaterials
(Related Publications)
Capturing Devices for Specific Target Cells
(Related Publications)
Nano-scale Polymer-Cell Interactions
(Related Publications)
Fundamental Polymer Science
(Related Publications)

Publications (2007-2012)

1.       Yang Y, Bugno J, and Hong S, Nanoscale Polymeric Penetration Enhancers in Topical Drug Delivery. Polymer Chemistry 2013, In Press.


2.       Pearson RM, Niladri P, Hsu HJ, Uddin S, Kral P, and Hong S, Positively Charged Dendron Micelles Display Negligible Cellular Interactions. ACS Macro Letters 2013, 2(1), 77-81.


3.       Sunoqrot S, Liu Y, Kim DH, and Hong S, Dendrimer-Polymer Hybrid Nanoparticles with Kinetically Controlled, Janus-Fasced Cellular Interactions.  Molecular Pharmaceutics 2013, ASAP Article.


4.       Guo L, Ferhan AR, Chen H, Li C, Chen G, Hong S, and Kim DH, Distance-mediated Plasmonic Dimers for Reusable Colorimetric Switches: A measurable peak shift of over 60 nm. Small 2013, 9(2), 234-240.


5.       Gonzalez L, Loza RJ, Hang KY, Sunoqrot S, Cunningham C, Purta P, Drake J, Jain S, Hong S, Chang JH, and Azar DT, Nanotechnology in Corneal Neovascularization Therapy. Journal of Ocular Pharmacology and Therapeutics 2012, In Press.


6.       Shen H, Banerjee AA, Mlynarska P, Hautman M, Hong S, Kapetanovic IM, Lyubimov AV, and Liu Y, Enhanced Oral Bioavailability of a Cancer Preventive Agent (SR13668) by Employing Polymerica Nanoparticles with High Drug Loading. Journal of Pharmaceutical Sciences 2012, 101(10), 3877-3885.


7.       Myung JH, Gajjar KA, Han YE, and Hong S, The Role of Polymers in Detection and Isolation of Circulating Tumor Cells. Polymer Chemistry 2012, 3(9), 2336-2341.


8.       Pearson RM, Sunoqrot S, Hsu HJ, Bae JW, and Hong S, Dendritic Nanoparticles: The next generation of nanocarriers? Therapeutic Delivery 2012, 3(8), 941-959.


9.       Yang Y, Sunoqrot S, Stowell C, Ji J, Lee CW, Kim JW, Khan SA, and Hong S, Effect of Size, Surface Charge, and Hydrophobicity of Poly(amidoamine) (PAMAM) Dendrimers on Their Skin Penetration Biomacromolecules 2012, 13(7), 2154-2162.


10.    Sunoqrot S, Bae JW, Pearson RM, Shyu K, Liu Y, Kim DH, Hong S, “Temporal Control over Cellular Targeting through Hybridization of Folate-targeted Dendrimers and PEG-PLA Nanoparticles" Biomacromolecules 2012 Apr 9; 13(4):1223-30. 

11.    Launiere CA, Gaskill M, Czaplewski G, Myung JH, Hong S, Eddington DT. "Channel Surface Patterning of Alternating Biomimetic Protein Combinations for Enhanced Microfluidic Tumor Cell Isolation" Analytical Chemistry 2012 May 1; 84(9):4022-8. 

12.    Myung JH, Gajjar KA, Saric J, Eddington DT, Hong S. "Dendrimer-mediated Multivalent Binding for Enhanced Capture of Tumor Cells" Angewandte Chemie International Edition 2011, 50(49), 11769-11772. 

13.    Bae JW*, Pearson RM*, Patra N, Sunoqrot S, Vukovi L, Kral P, Hong S. "Dendron-mediated Self-assembly of Highly PEGylated Block Copolymers: A Modular Nanocarrier Platform"Chemical Communications 2011, 47(37), 10302-10304. *denotes co-first authors. 

14.    Sunoqrot S, Bae JW, Jin SE, Pearson RM, Liu Y, Hong S. "Kinetically Controlled Cellular Interactions of Polymer-Polymer and Polymer-Liposome Nanohybrid Systems" Bioconjugate Chemistry 2011, 22(3), 466-474. 

15.    Shen H, Hong SPrud'homme RK, Liu Y. "Self-Assembling Process of Flash Nanoprecipitation in a Multi-inlet Vortex Mixer (MIVM) to Produce Drug-Loaded Polymeric Nanoparticles"Journal of Nanoparticle Research 2011, 13(9), 4109-4120. 

16.    Launiere CA, Czaplewski GJ, Myung JH, Hong S, Eddington DT. "Rheologically Biomimetic Cell Suspensions for Decreased Cell Settling in Microfluidic Devices" Biomedical Microdevices 2011, 13(3), 549-557. 

17.    Myung JH, Gajjar KA, Pearson RM, Launiere CA, Eddington DT, Hong S. "Direct Measurements on CD24-Mediated Rolling of Human Breast Cancer MCF-7 Cells on E-selectin"Analytical Chemistry 2011, 83(3), 1078-1083. 

18.    Jin SE, Bae JW, Hong S. Multiscale observation of biological interactions of nanocarriers: From nano to macro. Microsc Res Tech. 2010 Sep; 73(9): 813-23. DOI 

19.    Myung JH, Launiere CA, Eddington DT, Hong S. Enhanced Tumor Cell Isolation by a Biomimetic Combination of E-selectin and anti-EpCAM: Implications for the Effective Separation of Circulating Tumor Cells (CTCs). Langmuir. 2010 Jun 1; 26(11) 8589-96. DOI 

20.    Hong S, Rattan R, Majoros IJ, Mullen DG, Peters JL, Shi X, Bielinska AU, Blanco L, Orr BG, Baker JR, and Banaszak Holl MM, The Role of Ganglioside GM1 in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers Bioconjugate Chemistry, 2009 August 19; 20(8); 1503-13. 

21.    Chen J, Hessler JA, Putchakayala K, Panama BK, Khan DP, Hong S, Mullen DG, DiMaggio SC, Som A, Tew GN, Lopatin AN, Baker JR, Banaszak Holl MM, and Orr BG, Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes, Journal of Physical Chemistry B, 2009; 113(32); 11179-85. 

22.    Kim Y, Han SI, Hong S. Effect of modified carbon nanotube on the properties of aromatic polyester nanocomposites. Polymer. 2008;49(15):3335-45. DOI 

23.    Landmark KJ, DiMaggio S, Ward J, Vogt S, Hong S, Kotlyar A, Penner-Hahn JE, Baker JR, Banaszak Holl MM, Orr BG. Synthesis, Characterization, and In Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers. ACS Nano. 2008; 2(4): 773-783. DOI 

24.    Karnik R, Hong S, Zhang HM, Y, Anderson DK, JM, Langer R. Nanomechanical Control of Cell Rolling in Two Dimensions through Surface Patterning of Receptors. Nano Letters. 2008; 8(4): 1153-1158. DOI 

25.    Mahdavi A, Ferreira L, Sundback C, Nichol JW, Chan EP, Carter DJD, Bettinger CJ, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos PT, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM. A biodegradable and biocompatible gecko-inspired tissue adhesive. Proceedings of the National Academy of Sciences of the United States of America 2008;105 (7):2307-12. DOI 

26.    Karp JM, Mahdavi A, Hong S, Khademhosseini A, Langer R. Microscale Approaches for Bone Tissue Engineering. In: Khademhosseini A, Borenstein J, Takayama S, Toner M, editors. Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Norwood, MA: Artech House, Inc., 2008. 

27.    Peer D*, Karp JM*, Hong S*, FaroKhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotechnology 2007;2(12): 751-60. *co-first authors 

28.    Nam YW, Kim WN, Cho YH, Chae DW, Kim GH, Hong S, Hwang SS, Hong SM. Morphology and Physical Properties of Binary Blend Based on PVDF and Multi-Walled Carbon Nanotube. Macromolecular Symposia 2007;249-250:478-84. DOI 

29.    Leroueil PR, Hong S, Mecke A, Baker JR, Orr BG, Banaszak Holl MM. Nanoparticle interaction with biological membranes: Does nanotechnology present a janus face? Accounts of Chemical Research 2007;40 (5):335-42. DOI 

30.    Hong S, Mecke A, Leroueil PR, Banaszak Holl MM, Orr BG. Dendrimer-Bilayer Interactions. In: Majoros I, Baker J, editors. Dendrimer Based Nanomedicine. Hackensack, NJ: World Scientific Publishing, 2007. 

31.    Hong S, Leroueil PR, Majoros IJ, Orr BG, Baker JR, Banaszak Holl MM. The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chemistry & Biology 2007;14 (1):107-15. DOI 

32.    Hong S, Lee D, Zhang H, Zhang JQ, Resvick JN, Khademhosseini A, King MR, Langer R, Karp JM. Covalent immobilization of P-selectin enhances cell rolling. Langmuir 2007;23:12261-8.DOI 

33.    Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer RS, Farokhzad OC. Targeted nanoparticles for cancer therapy. Nano Today 2007;2 (3):14-21. DOI 

34.    Chae DW, Hwang SS, Hong SM, Hong S, Cho BG, Kim BC. Influence of high contents of silver nanoparticles on the physical properties of poly(vinylidene fluoride). Molecular Crystals and Liquid Crystals 2007;464:815-23. DOI