Department of Biopharmaceutical Sciences

College of Pharmacy

Zaijie Jim Wang, Ph.D.

Zaijie Jim Wang, Ph.D.

Professor, Pharmacology and Pharmaceutics

Contact Information
833 South Wood Street
3320 MBRB, MC 865
Chicago, IL 60612-7231
Office: (312) 355-1429
Fax: (312) 996-0098
Lab Website


Ph.D. - University of California at San Francisco - 1996

Research Interests

Molecular mechanisms of opioid tolerance and substance abuse
(Related Publications)

G protein-coupled receptor; signal transduction, phosphorylation, and trafficking
(Related Publications)

Molecular mechanisms, interventions and targeting of neuropathic pain
(Related Publications)


Publications (2007-2012)

Webster DE, He Y, Chen S-N, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol. 2011 Jan 1;81(1):170-7.

He Y, Yang C, Kirkmire CM, Wang ZJ. Regulation of opioid tolerance by let-7 family microRNA targeting the μ opioid receptor. J Neurosci. 2010 Jul 28; 30(30):10251-8.

Chen Y, Yang C, Wang ZJ. AMKIIα is required for the initiation and maintenance of opioid-induced hyperalgesia. J Neurosci. 2010 Jan 6; 30(1):38-46.

Wilkie DJ, Molokie R, Boyd-Seale D, Suarez ML, Kim YO, Zong S, Wittert H, Zhao Z, Saunthararajah Y, Wang ZJ. Patient-Reported Outcomes: Descriptors of Nociceptive and Neuropathic Pain and Barriers to Effective Pain Management in Adult Outpatients with Sickle Cell Disease. J Nat Med Assoc. 2010 Jan; 102(1): 18-27.

Wang ZJ, Wilkie DJ, Molokie RE. Neurobiological Mechanisms of Pain in Sickle Cell Disease. Hematology Am Soc Hemetol Educ Program. 2010; 2010: 403-8.

Chen Y, Luo F, Yang C, Kirkmire C, Wang ZJ. Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice. J Pharmacol Exp Ther. 2009 Aug; 330(2): 650-9. Epub 2009 May 28.

Webster, D.E., Dentali, S. Farnsworth, N.F., Wang, Z.J. Chaste tree and premenstrual syndrome. in Natural Medications for Psychiatric Disorders:Considering the Alternatives Eds. Mischoulon, D. Rosenbaum, J.E. Philadelphia, Lippincott Williams & Wilkins, 2008; 216-227.

Luo F, Yang C, Chen Y, Shukla P, Tang L, Wang LX, Wang ZJ. Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinaseII. J Pharmacol Exp Ther. 2008 Apr;325(1):267-75. Epub 2008 Jan 4. DOI

Tang L, Chen, Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea (IBTU), a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. J Pharmacol Exp Ther. 2007 May;321(2):791-8. Epub 2007 Feb 20. DOI

Tang L, Shukla PK, Wang ZJ. Disruption of acute opioid dependence by antisense oligodeoxynucleotides targeting neurogranin. Brain Res. 2007 Apr 27;1143:78-82. Epub 2007 Jan 25. DOI

Nissan HP, Lu J, Booth NL, Yamamura HI, Farnsworth NR, Wang ZJ. A red clover (Trifolium pratense) phase II clinical extract possesses opiate activity. J Ethnopharmacol. 2007 May 30;112(1):207-10. Epub 2007 Feb 11. DOI

Rhyu MR, Lu J, Webster DE, Fabricant DS, Farnsworth NR, Wang ZJ. Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor. J Agric Food Chem. 2006 Dec 27;54(26):9852-9857. DOI

Tang L, Shukla PK, Wang LX, Wang ZJ. Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca2+/calmodulin-dependent protein kinase II. J Pharmacol Exp Ther. 2006 May;317(2):901-9. DOI

Shukla PK, Tang L, Wang ZJ. Phosphorylation of neurogranin, protein kinase C, and Ca(2+)/calmodulin dependent protein kinase II in opioid tolerance and dependence. Neurosci Lett. 2006;404(3):266-9. DOI

Tang L, Shukla PK, Wang ZJ. Attenuation of opioid tolerance by antisense oligodeoxynucleotides targeting neurogranin. Eur J Pharmacol Rapid Comm. 2006;542(1-3):106-7S. DOI

Bhalla S, Ciaccio N Wang ZJ, Gulati A. Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells. Exp Biol Med. 2006;231(6):1152-6. DOI

Wang ZJ, Wang LX. Phosphorylation--A molecular switch in opioid tolerance (Invited review) Life Sci. 2006 Sep 27;79(18):1681-91. Epub 2006 Jun 2. DOI

Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Fong H.H.S. Farnsworth NR, Pauli GF. A novel GABAergic phthalide dimer from Angelica sinensis (Oliv.) Diels, Phytochemical Anal. Phytochem Anal. 2006 Nov;17(6):398-405.

Tang L, Shukla PK, Wang ZJ. Trifluoperazine, an orally available clinically used drug, disrupts opioid antinociceptive tolerance. Neurosci Lett. 2006 Apr 10-17;397(1-2):1-4. Epub 2005 Dec 27. DOI

Webster DE, Lu J, Chen S-N, Farnsworth NR, Wang ZJ. Activation of the ยต-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006 Jun 30; 106(2): 216-21. Epub 2006 Jan 24. DOI

Lu J, Jeon E, Lee BS, Onyuksel H, Wang ZJ. Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes. J Control Release, 2006;110(3):505-513. DOI

Gardell LR, Ibrahim M, Wang R, Wang ZJ, Ossipov MH, Malan TP, Porreca F, Lai J. Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Neurosci. 2004;123:43-52. DOI