Department of Pharmacy Practice

College of Pharmacy

Multinational Evaluation of Conditional Median Models

Multinational Evaluation of Conditional Median Models of EQ-5D
Health State Preferences Poster


   James W. Shaw PhD, PharmD, MPH (Department of Pharmacy Administration/UIC), Simon Pickard PhD (Department of Pharmacy Practice/UIC) and colleagues (Lin Zhan MS and Mark Oppe MSc) presented a poster entitled “Multinational Evaluation of Conditional Median Models of EQ-5D Health State Preferences” at the 17th Annual Conference of the International Society for Quality of Life Research (ISOQOL), which was held October 27-30, 2010 in London, England. ISOQOL is an international scientific organization dedicated to advancing the study of health-related quality of life and other patient-centered outcomes. There were more than 300 posters that were presented at the conference and were organized into methodology, clinical research, and policy research tracks. Dr. Shaw and his colleagues were granted the Best Policy Research Poster Award for their research.

     The EQ-5D questionnaire is designed to measure an individual’s point-in-time health status. It uses 5 questions to measure the severity of problems with mobility, the performance of self-care activities, the performance of usual activities, pain/discomfort, and anxiety/depression. Combinations of responses to these questions describe a total of 243 unique health states. By assigning population preferences to individuals’ self-classified EQ-5D health states, one can derive quality-adjusted life years for use in economic evaluations of pharmaceuticals and other health care technologies.

     Until recently, researchers have emphasized the estimation and application of mean societal preferences for EQ-5D health states. For most states of health, the mean provides an inadequate measure of the central tendency of population preferences. Over the past several years, Dr. Shaw has led several studies involving the characterization of median population preferences for health states described by the EQ-5D questionnaire. As compared with the mean, the median provides a fairer representation of the aggregate preference of all population members. Both the mean and median are amenable for use in decision analytic applications.

     The study presented by Dr. Shaw and colleagues involved an evaluation of estimators of median population EQ-5D health state preferences using data collected in four countries. Much of Dr. Shaw’s prior research has focused on the US population. This study provided evidence regarding the suitability of median preference estimators for countries outside the US. Although the authors observed differences among the four countries, their findings supported the feasibility of median preference estimation. This work has implications for the methods used to estimate preferences for the health states described by the EQ-5D and similar questionnaires.

Click here for the research poster.

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