Pharmacy Practice Sponsored Research
Jeffrey Bishop, PharmD
Risperidone Pharmacogenetics: The Role of the Type 3 Metabotropic Glutamate Receptor in Cognition and Negative Symptom Response
Sponsor: National Alliance for Research on Schizophrenia and Depression (NARSAD)
Summary: The purpose of this study is to investigate the relationship between markers in a metabotropic glutamate receptor gene and cognitive and symptom outcomes in patients treated with risperidone.
Schizophrenia Pharmacogenetics cognition and symptom response to antipsychotics
Sponsor: National Institute of Mental Health
Summary: The purpose of this study is to investigate the relationship between genetic markers and cognitive and symptom outcomes in patients with schizophrenia who are treated with antipsychotic agents.
Clinical and Computational Studies of Dopamine Function in First Episode Schizophrenia
Sponsor: Ortho McNeil-Janssen Pharmaceuticals
Summary: This is a drug supplement study to provide medication to participants in an ongoing collaboration to investigate drug effects on cognition in first episode schizophrenia patients.
Larisa Cavallari, PharmD
Genetic determinants of aldosterone escape in heart failure
Sponsor: National Institutes of Health
Summary: Heart failure is the most common cause for hospitalization, particularly in the elderly. Aldosterone is a hormone that promotes heart failure development and progression. This study aims to determine whether a person's genetic makeup affects his or her risk for elevated aldosterone levels despite standard therapy in heart failure.
Larry Danziger, PharmD
Patient Characteristics and awareness about Appropriate Waste Disposal
Sponsor: Metropolitan Water Reclamation
Summary: Prescription sales reached 286.5 billion in 2007. Despite high yearly prescription sales, many of these prescriptions will go unused for various reasons such as, improved patient condition, the inability to tolerate adverse effects of the drug, changes in dosage or medication regimen, death, or medication expiration. Oftentimes, these unwanted or expired medications are just stored in the home indefinitely or disposed of via the sink, flushed down the toilet, or tossed in the garbage.
The storage or disposal of unwanted or expired medications in this way poses a serious health risk. Children and pets may be exposed to these medications if kept in the home or thrown in the garbage resulting in accidental exposure and toxic effects. Also, medications found in the garbage also have the potential to be abused especially narcotic pain relievers, sleep aids, etc.
There is growing concern about the safety of the national water supply, with regards to pharmaceuticals, due to recent reports of the detection of antibiotics, antidepressants and hormone replacement medications in waterways nationwide. Trace amounts of pharmaceuticals and their metabolites have also been identified in some drinking water supplies. This results from pharmaceuticals passing through water treatment facilities and domestic sewage systems that are not specifically designed to remove them from circulation. Additionally, medication waste dumped at landfills may also make its way to the groundwater supply. Although using the toilet or sink prevents someone from accidentally taking the medications, disposing of them in this way causes inadvertent contamination which is believed to have caused adverse effects on many aquatic species. Moreover, there is the concern/potential for humans to be affected by this inadvertent environmental contamination by these pharmaceuticals. For example, the release of antibiotics in the environment may foster the spread of antibiotic resistance among microorganisms present in the waterways.
Preliminary reports in the literature indicate most patients are not only unaware of who provides medication disposal programs but they are also unsure of how to properly dispose of medications. Also, there is a lack of consistency in who provides drug disposal programs in the United States. Unfortunately, many local pharmacies refuse to accept returned medications because they do not have the means to adequately destroy these medications these medications and more importantly, it is against the law in some state.
The objective of our study is to determine how patients use, store, and dispose of expired or unused medications.
Robert Didomenico, PharmD
Digoxin Dosing In Heart Failure A Simplified Nomogram Vs Standard Care
Sponsor: American College of Clinical Pharmacy Research
Summary: Dosing methods for digoxin, a drug used to treat heart failure, have not been updated in decades despite evidence in recent years suggesting that blood levels of digoxin achieved with traditional dosing practices may increase the risk of adverse events. We developed a simple dosing tool that targets lower blood levels of digoxin that have been associated with improved outcomes compared to higher blood levels. The aim of this study is to determine if this simplified dosing tool is more effective than standard digoxin dosing practices at achieving lower blood levels and also to determine if digoxin dosing may be further optimized by incorporating patients’ genetic information believed to influence the drug’s properties.
James Fischer, PharmD
A Sequential Open -Label Study of the Pharmacokinetics and Safety of Intravenous Carbamazepine Relatitve to Oral Carbamazepine
Sponsor: Ovation Pharmaceuticals
Summary: Carbamazepine is a common medication for treating seizures. It is available as tablets, capsules, and a liquid that are taken by mouth. The lack of availability of methods other than orally for giving carbamazepine, such as through a vein (IV), prevents its use when individuals are unable to take it by mouth. In the past, problems with dissolving carbamazepine in water hampered the development of an IV formulation. This study tests the safety, tolerability, and pharmacokinetics (how drugs are taken in, handled and eliminated by the the body) of an investigational IV form of carbamazepine in patients receiving oral carbamazepine for treatment of their epilepsy. The IV formulation uses a chemical called captisol (a beta-cyclodextrin derivative) to assist in dissolving carbamazepine in water.
Kristen Goliak, PharmD
Medication Monitoring and Safety in Older Adults A Community Based Education Program
Sponsor: Age Options
Hyun-young Jeong, PharmD, PhD
Effects of Female Hormones on Hepatic Drug Metabolism Clinical Implication during Pregnancy
Sponsor: American College of Clinical Pharmacy Research
Summary: The primary goal in this research project is to establish a firm link between the female hormones and altered hepatic elimination of drugs iin vitro systems, and to predict altered pharmokinetics of drugs during pregnancy using human hepatocytes.
Effects of female hormones on hepatic drug metabolism: clinical implication during pregnancy
Sponsor: National Institute of Child Health & Human Development
Alan Lau, PharmD
AMG 223 In Dialysis Patients With Hyperphosphatemia
Sponsor: Amgen Inc.
Eifficacy of phosphate binding in hemodailysis Patients Chew vs Crushed Lanthanum
Sponsor: Shire US Inc.
Todd Lee, PharmD, PhD (PI), Simon Pickard, PhD (CO-I), Glen Schumock, PharmD, MBA (CO-I)
CONCERT Clinical Effectiveness Research (CONCERT-CER)
Sponsor: National Heart, Lung, and Blood Institute
Summary: UIC serves as a subcontract to the University of Chicago, and will be responsible for leading the evaluation of the comparative effectiveness of medication therapies in patients with COPD. A research team will examine the relative value of interventions in treatments of patients with COPD.
Tracie Locklear, PharmD
Chemopreventative properties of Medicinal and Food plants of the Lumbee Tribe
Sponsor: National Center for Complementary & Alternative Medicine
Summary: Native American women have a reduced incidence of breast cancer relative to other ethnic groups. In fact, the Lumbee Tribe, the 9th largest Native American tribe in the United States, experiences only about half the incidence of breast cancer as their non-Hispanic and African American counterparts. The reasons for this are unclear; however, the Lumbee associate certain medicinal and food plants with cancer treatment and prevention. The focus of this investigation is to examine medicinal and food plants of the Lumbee Tribe for breast cancer chemopreventive properties. According to published literature about the medicinal use of plants among this tribe, seven commonly used botanicals were selected for collection and evaluation. These were: Antirrhinum majus (L.), Brassica oleracea (L.), Chimaphila maculata (L.), Daucus carota (L.), Diospyros virginiana (L.), Hydrastis canadensis (L.), and Prunella vulgaris (L.).
Simon Pickard, PhD
TAP- UIC Fellowship in Health Economics and Outcomes Research
Sponsor: TAP Pharmaceutical Products, Inc.
Novo Nordisk & Univ of ILL at Chicago Fellowship in Health Economics and Outcomes Research
Sponsor: Novo Nordisk Pharmaceuticals
Comparative Effectiveness of Tiotropium in patients with Chronic Obstructive Pulmonary Diseases (COPD)
Sponsor: Agency for Healthcare Research & Quality
Summary: The overall goal of this project is to evaluate the comparative effectiveness of tiotropium to other COPD medications when used to modify an existing treatment regimen. This is vital to providers of a Part D benefit as triotropium likely has a major impact with respect to their respiratory benefit costs and a better understanding of its comparative effectiveness may help guide positioning on their formularies.
Keith Rodvold, PharmD
Phase I Clinical Studies Of Chemopreventive Agents
Sponsor: National Cancer Institute
Doripenem Intrapulmonary Pharmacokinetics in Healthy Adult Subjects
Sponsor: Ortho-McNeil Janssen Pharmaceuticals
Doripenum Disposition in Cerebrospinal Fluid in Subjects with External Ventriculostomy
Sponsor: Ortho-McNeil Janssen Pharmaceuticals
Glen Schumock, PharmD
Hospital Medicine and Economics Center for Education and Research for Therapeutics (CERT)
Sponsor: University of Chicago
Summary: This grant includes two projects that are conducted as part of the University of Chicago CERT funded by the Agency for Healthcare Research and Quality. Dr. Schumock serves as co-investigator for the projects titled “Validating performance measures for patients hospitalized with COPD exacerbations” (project 1) and 2) “Using social network analysis to guide quality improvement team formation”. The first project seeks to validate the use of ICD-9-CM codes form billing data for identifying patients with COPD for quality improvement initiatives. The second project seeks to understand how social network mapping might be used to inform the development of more effective quality improvement teams.
General DEcIDE Network Support: Methods and Dissemination
Sponsor: Agency for Healthcare Research & Quality
Summary: This contract provided general support to the Chicago-Area DEcIDE Center for participation in AHRQ working groups to develop guidelines/white papers on recommended methods to using when conducting comparative effectiveness research, and for other AHRQ-related work that is not specific to another task order.
Eljim Tesoro, PharmD
Anidulafungin Pharmacokinetics in Patients with Septic Shock and Hypoalbuminemia
Sponsor: Pfizer Inc.
Summary: This study will provide information on the pharmacokinetics of anidulafungin in critically ill patients with septic shock and hypoalbuminemia. Such information will be valuable in helping determine the optimal dose for this population.
2009 Pharmacy Residency Stipend Support Program
Sponsor: Amgen Inc.
Daniel Touchette (PI), Vicki Groo (Co-I)
Assessment of a Telepharmacy Robotic Medication Dispensing Unit in Military Warrior Transition Units
Sponsor: INRange Systems
Summary: This study involves the use of an electronic medication management assistant, or EMMA delivery unit, designed to remotely deliver, manage and monitor a patient's drug therapy and adherence in the outpatient setting under the guidance of a physician, nurse case manager and pharmacist.