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 Dr. Thatcher's Selected Publications
  1. Brian M. Bennett, James, N. Reynolds, Glen T. Prusky, Robert M. Douglas, Robert J. Sutherland, Gregory R.J. Thatcher,  Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester, Neuropsychopharmacol, (2007), 32, 505-513 .

  2. Gregory R. J. Thatcher, James N. Reynolds , Brian M. Bennett, Nitric oxide chimeras for treatment of  Alzheimer¡¯s disease, Curr. Alzheimer¡¯s Res., (2006) in press.

  3. Hong Liu, Judy L. Bolton, and Gregory RJ Thatcher,. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4¡¯F-DMA, a new benzothiophene selective estrogen receptor modulator.  Chem. Res. Toxicol. (2006) in press..

  4. Jennifer L Clarke, Irida Kastrati, Linda Johnstone, Gregory RJ Thatcher, Photochemical reactions of thiols with organic nitrates: oxygen atom transfer, Can. J. Chem. (2006) Special Issue; in press..

  5. Adrian C Nicolescu, Qian Li, Laurie Brown, Gregory RJ Thatcher, Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS , Nitric Oxide: Biology & Chemistry, (2006), in press.

  6. Ju Liu, Qian Li, Minsun Chang, Richard B. van Breemen, Judy L. Bolton, and Gregory R. J. Thatcher. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chem. Res. Toxicol. 18 (2005) 1485-96.

  7. Gregory R. J. Thatcher,   An introduction to NO related therapeutics, Curr. Top. Med. Chem.  5 (2005) 597-601.

  8. Gregory R. J. Thatcher, James N. Reynolds , Brian M. Bennett, Nitric oxide mimetic molecules as therapeutic agents in Alzheimer¡¯s disease, Curr. Alzheimer¡¯s Res., 2 (2005) 171-182.

  9. Hong Liu, Linning Yu , Yanan Yang, Ju Liu, Gregory R. J. Thatcher, Richard B. van Breemen, and Judy L. Bolton . Bioactivation of the SERM desmethylated arzoxifene to quinoids: 4¡¯-fluoro substitution prevents quinoid formation. Chem. Res. Toxicol. 18 (2005) 162-173.

  10. Ju Liu, Hong Liu, Richard B. van Breemen, Gregory R. J. Thatcher, and Judy L. Bolton . Bioactivation of the SERM acolbifene to quinone methides. Chem. Res. Toxicol. 18 (2005) 174-182.

  11. Gregory R. J. Thatcher, Adrian Nicolescu, Brian M. Bennett, and Violeta Toader , Nitrates & NO release: contemporary aspects in biological and medicinal chemistry Free Rad. Biol. Med., (2004) 37, 1122-43.

  12. Gregory R. J. Thatcher, James N. Reynolds , Brian M. Bennett, Novel nitrates as NO mimetics directed at Alzheimer¡¯s disease, J. Alzheimers Dis., (2004) 6, 6S, S75-S84.

  13. Zhiqiang Wang , Lei Chang , William L. Klein , Duane L. Venton, and Gregory R.J. Thatcher, Per-6-substituted-per-6-deoxy ¦Â-cyclodextrins inhibit the formation of ¦Â-amyloid-peptide (A¦Â) derived, soluble oligomers (ADDLs) J. Med. Chem., 47 (2004) 3329-3333

  14. Linning Yu , Hong Liu , Wenkui Li, Fagen Zhang, Connie Meloche, Richard van Breemen, Gregory R. J. Thatcher, and Judy L Bolton, Quinoids formed from estrogens and antiestrogens, Chem. Res. Toxicol., 17 (2004) 879-888.

  15. Adrian C. Nicolescu , James, N. Reynolds, L. Ross Barclay , and Gregory R.J. Thatcher, Organic Nitrites and NO: Inhibition of lipid peroxidation and radical reactions, Chem. Res. Toxicol., 17 (2004) 185-96.

  16.   Judy L. Bolton , Linning Yu , and Gregory R.J. Thatcher, Quinoids formed from estrogens and antiestrogens, Meth. Enzymol. 378 (2004) 110-123.

  17. Violeta Toader, Adrian C. Nicolescu , Xudong Xu, Linning Yu , Judy L. Bolton ,  and Gregory R.J. Thatcher, Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, RNOS, and peroxynitrite, Chem. Res. Toxicol., 16 (2003) 1264-76.

  18.  Akhter, S.; Green, J. R.; Root, P.; Thatcher, G. R. J.; Mutus, B. Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications.  Nitric Oxide 8 (2003) 214-221

  19. Jon Difabio, Yanbin Yi, Vasilis Vasiliou, Gregory R.J. Thatcher, and Brian M. Bennett, Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Mol. Pharmacol. 64 (2003) 1109-16.

  20.  Erwin Buncel, Ruby Nagelkerke , and Gregory R. J. Thatcher, Alkali metal-ion catalysis in nucleophilic displacement by ethoxide ion on p-nitrophenyl phenylphosphonate: Evidence for multiple metal ion catalysis, Can. J. Chem. 81 (2003) 53.


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