Bioengineering (BIOE)

Subject Number Title Hours Catalog Description
BIOE 101 Introduction to Bioengineering 2 hours. Overview of how the principles and techniques of engineering are applied to help solve problems in the medical and biological sciences. Curricular and career paths discussed; projects, research lab and facility tours. 
BIOE 205 Bioengineering Thermodynamics 3 hours. Introduction to equilibrium and non-equilibrium thermodynamics, with emphasis on non-equilibrium (living) systems.  Applications include thermodynamics of living cells and the lung, molecular energy exchange, and energy exchange in exercise. Prerequisite(s): PHYS 142.
BIOE 240 Modeling Physiological Data and Systems 3 hours. A lecture/discussion course introducing the use of mathematical models and statistics to describe, interpret and analyze physiological data and systems. Prerequisite(s): BIOS 100 and MATH 180. Open only to freshmen and sophomores.
BIOE 250 Clinical Problems in Bioengineering 3 hours. Examination of three to four real problems in bioengineering. Student teams work with a faculty facilitator toward each solution. Problem identification, strategic planning, brainstorming, information gathering and reporting are formalized. Prerequisite(s): BIOE 101. Open only to freshmen and sophomores.
BIOE 310 Biological Systems Analysis 3 hours. System dynamics and frequency-domain analysis in bioengineering systems. Topics include population models, predator-prey models, metabolic networks, biological oscillation, dynamics of infectious diseases. No credit given if the student has credit in ECE 310 or ME 312. Prerequisite(s): MATH 220.
BIOE 325 Biotransport 3 hours. Transport phenomena in biomedical engineering and living systems, specifically processes vital to the design of medical devices for artificial clinical intervention.  Topics include circulatory system dynamics and modeling of physiological systems. Prerequisite(s): MATH 220 and BIOS 100.
BIOE 339 Biostatistics I 3 hours. Statistical treatment of data and model estimation treated in a framework of biological experiments, and attributes of data generated from such experiments. Experimental design is included.  Extensive computer use required.  Prerequisite(s): MATH 210; and CS 107 or CS 108 or CS 109. Recommended Background: Prior knowledge of Excel.
BIOE 396 Senior Design I 3 hours. Design considerations for biomedical devices emphasizing traditional engineering design concepts. Prerequisite(s): Credit or concurrent registration in BIOE 339.
BIOE 397 Senior Design II 3 hours. Application of principles of engineering and engineering design methodology to the solution of a large scale biomedical engineering design problem. Prerequisite(s): BIOE 396. 
BIOE 398 Undergraduate Research 1 TO 5 hours. Research under the close supervision of a faculty member. May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor. 
BIOE 402 Medical Technology Assessment 2 OR 3 hours. Bioentrepreneur course.  Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.
BIOE 405 Atomic and Molecular Nanotechnology 3 OR 4 hours. Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and atomic force microscopy, quantum mechanical phenomena. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major.
BIOE 406 Regulation and Manufacturing Practices in Medical Technology 2 OR 3 hours. Bioentrepreneur course. Product requirement definition, FDA, quality system regulation, community Europe, medical device directive, role of management, United States pharmacopoeia, toxicity testing, hazard analysis, risk assessment, import/export. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.
BIOE 407 Pattern Recognition I 3 OR 4 hours. The design of automated systems for detection, recognition, classification and diagnosis. Parametric and nonparametric decision-making techniques. Applications in computerized medical and industrial image and waveform analysis. Same as ECE 407. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): MATH 220. 
BIOE 408 Medical Product Development 2 OR 3 hours. Bioentrepreneur course. Major stages of medical product development (investigative, feasibility, development, commercialization, maturation and growth), regulatory issues, product performance, failure mode and effect analysis, hazard analysis. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.
BIOE 410 FDA and ISO Requirements for the Development and Manufacturing of Medical Devices 3 OR 4 hours. FDA Performance Standard for General Medical Devices for manufacturing and development engineers. Product requirement definition, design control, hazard analysis, failure mode and effect analysis, regulatory submission, product tests, ISO 9001. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and BIOE 250. Recommended background: Junior standing or above.
BIOE 415 Biomechanics 3 OR 4 hours. Use of rigid and deformable body statics and rigid body dynamics to analyze various aspects of the human musculoskeletal system. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 201 and ME 210; and BIOS 430 or BIOS 443 or BIOS 484 or BIOS 485.
BIOE 420 Introduction to Field and Waves in Biological Tissues 3 OR 4 hours. Principles of electromagnetic and ultrasonic interaction with biological systems; characterization of biological materials; diagnostic and therapeutic uses; and techniques of dosimetry and measurement. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): ECE 310. 
BIOE 421 Biomedical Imaging 3 OR 4 hours. Introduction to engineering and scientific principles associated with X-ray, magnetic resonance, ultrasound, computed tomographic and nuclear imaging. 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): MATH 210 and PHYS 142. 
BIOE 430 Bioinstrumentation and Measurements I 3 OR 4 hours. Theory and application of instrumentation used for physiological and medical measurements. Characteristics of physiological variables, signal conditioning devices and transducers. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100; and ECE 115 or ECE 210 or ECE 225; and BIOE 310 or ECE 310 or ME 312.
BIOE 431 Bioinstrumentation and Measurement Laboratory 2 hours. Practical experience in the use of biomedical instrumentation for physiological measurements. Prerequisite(s): Credit or concurrent registration in BIOE 430. 
BIOE 432 Bioinstrumentation and Measurements II 3 OR 4 hours. Principles of bioinstrumentation for the assessment of physiological function and therapeutic intervention. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 430. 
BIOE 433 Bioinstrumentation and Measurements II Laboratory 1 hour. Laboratory experiments using instruments to assess physiological function. Prerequisite(s): Credit or concurrent registration in BIOE 432. 
BIOE 439 Biostatistics II 4 hours. Statistical treatment of data, model estimation, and inference are treated in a framework of biological experiments and attributes of data generated from such experiments. Credit is not given for BIOE 439 if the student has credit for BSTT 400. Extensive computer use required.  Prerequisite(s): MATH 210 and CS 108; and consent of the instructor. Recommended background: Knowledge of MATLab.
BIOE 440 Biological Signal Analysis 3 OR 4 hours. Analysis of signals of biological origin. Transient signals. Stability analysis. Control. Probabilities, stochastic processes. Medical applications. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): MATH 210 and senior or graduate standing.
BIOE 450 Molecular Biophysics of the Cell 4 hours. Introduction to force, time energies at nanometer scales; Boltzmann distribution; hydrodynamic drag; Brownian motions; DNA, RNA protein structure and function; sedimentation; chemical kinetics; general aspects of flexible polymers. Same as PHYS 450. Prerequisite(s): PHYS 245 or the equivalent.
BIOE 452 Biocontrol 3 OR 4 hours. Considers the unique characteristics of physiological systems using the framework of linear systems and control theory. Static and dynamic operating characteristics, stability, and the relationship of pathology to control function. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): ECE 310; and either BIOS 442 or BIOS 443. 
BIOE 455 Introduction to Cell and Tissue Engineering 3 OR 4 hours. Foundation of cell and tissue engineering covering cell technology, construct technology, and cell-substrate interactions. Emphasis in emerging trends and technologies in tissue engineering. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and credit or concurrent registration in BIOE 430 or BIOS 443 or BIOS 484 or BIOS 485.
BIOE 456 Cell and Tissue Engineering Laboratory 2 hours. Includes polymer scaffold fabrication, microstamping biomolecules, cellular adhesion and proliferation assays, and immo/fluorescent tagging. Prerequisite(s): Credit or concurrent registration in BIOE 455; or consent of the instructor.
BIOE 460 Materials in Bioengineering 3 OR 4 hours. Analysis and design considerations of problems associated with prostheses and other implanted biomedical devices. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and BIOS 220 or BIOS 222 or BIOS 240, BIOS 286 or BIOS 352.
BIOE 465 Metabolic Engineering 3 OR 4 hours. Quantitative descriptions of biochemical networks; modeling, control, and design of metabolic pathways to achieve industrial and medical goals.  3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310 or ME 312; or consent of the instructor.
BIOE 470 Bio-Optics 3 OR 4 hours. Physical principles and instrumentation relevant to the use of light in biomedical research. Several current and developing clinical applications are explored. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): PHYS 142. 
BIOE 472 Models of the Nervous System 3 OR 4 hours. Mathematical models of neural excitation and nerve conduction, stochastic models and simululation of neuronal activity, models of neuron pools and information processing, models of specific neural networks. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310 or ME 312; and credit or concurrent registration in BIOS 484 or BIOS 485.
BIOE 475 Neural Engineering I: Introduction to Hybrid Neural Systems 3 OR 4 hours. Modeling and design of functional neural interfaces for in vivo and in vitro applications, electrodes and molecular coatings, neural prostheses and biopotential control of robotics. Same as BIOS 475. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 472; or consent of the instructor.
BIOE 476 Neural Engineering I Laboratory 2 hours. Hands-on experience with computational and experimental models of engineered neural systems, with emphasis on neuroprostheses and biosensors. Animals used in instruction. Prerequisite(s): Credit or concurrent registration in BIOE 475. 
BIOE 480 Introduction to Bioinformatics 3 OR 4 hours. Computational analysis of genomic sequences and other high throughput data. Sequence alignment, dynamic programming, database search, protein motifs, cDNA expression array, and structural bioinformatics. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and CS 201; or consent of the instructor. 
BIOE 481 Bioinformatics Laboratory 2 hours. How to use bioinformatics tools, including sequence alignment methods such as Blast, Fasta, and Pfam, as well as structural bioinformatics tools, such as Rasmol and CastP. Extensive computer use required. Prerequisite(s): Credit or concurrent registration in BIOE 480; and senior standing or above; and consent of the instructor. 
BIOE 482 Introduction to Optimization Methods in Bioinformatics 3 OR 4 hours. The objectives are to provide the students with a basis for understanding principles of the optimization methods and an insight on how these methods are used in bioinformatics. 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): BIOS 100 and CS 201. 
BIOE 483 Molecular Modeling in Bioinformatics 3 OR 4 hours. Basic structural and dynamics tools in protein structure prediction, structure comparison, function prediction, Monte Carlo and molecular dynamics simulations. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Grade of B or better in BIOE 480.
BIOE 494 Special Topics in Bioengineering 1 TO 4 hours. Special topics to be arranged. May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor.