Department of Biopharmaceutical Sciences

College of Pharmacy

Hayat Onyuksel, Ph.D.

Hayat Onyuksel, Ph.D.

Acting Assistant Head, Graduate Studies

Professor, Pharmaceutics and Bioengineering

Contact Information
833 South Wood Street
358 Pharm, MC 865
Chicago, IL 60612-7231
Office: (312) 996-2097
Fax: (312) 996-0098

Publications (2005-2009)
Drug Delivery Using Nanotechnology and Nanomedicine

Banerjee A,Onyuksel H. A Novel Peptide Nanomedicine for Treatment of Pancreatogenic Diabetes. Nanomedicine: Nanotechnology, Biology, and Medicine, In press, 2013.

Dagar A., Kuzmis A., Rubinstein I., Sekosan M., Onyuksel H. VIP-targeted Cytotoxic Nanomedicine for Breast Cancer. Drug Deliv. and Transl.Res. 2: 454-462, 2012.

Lim S.B, Banerjee A,Onyuksel H. Improvement of drug safety by the use of Lipid-based Nanocarriers. J.Control.Release 163: 34-45, 2012.

Williams R.L, Lim S.B, Onyuksel H, Marucha P.T. Sterically Stabilized Phospholipid Micelles Reduce Activity of a Candidate Antimicrobial Wound Healing Adjunct. Int J Pept Res Ther. 18: 195-203, 2012.

Vukovic L, Khatib F, Drake S, Madriaga A, Brandenburg K, Kral P, and Onyuksel H. Structure and Dynamics of Highly PEGylated Sterically Stabilized Micelles in Aqueous Media.J Am Chem Soc. 133:13481-13488, 2011.

Onyuksel H, Banerjee A . Phospholipid–based Nanomicelles in Cancer Nanomedicine. Nanomedicine in Health and Disease, Eds Hunter R.J and Preedy V.R. CRS Press, Chapter 16, pages 314-335, 2011.

Kuzmis A, Lim SB, Desai E, Jeon E, Lee BS, Rubinstein I, Onyuksel H. Micellar Nanomedicine of Human Neuropeptide Y. Nanomedicine. 2011 Aug; 7(4): 464-71. Epub 2011 Jan 25. DOI

Brandenburg K.S, Rubinstein I, Sadikot R.T, Onyuksel H. Polymyxin B Self-associated with Phospholipid Nanomicelles. Pharm. Dev. and Tech.,17: 654–660, 2012 DOI

Koo MY, Rubinstein I, Onyuksel H. Actively Targeted Low-Dose Camptothecin as a Safe, Long-Acting, Disease Modifying Nanomedicine for Rheumatoid Arthritis. Pharm Res. 28:776-787, 2011. DOI

Lim SB, Rubinstein I, Sadikot RT, Artwohl JE, Onyuksel H. A Novel Peptide Nanomedicine Against Acute Lung Injury:GLP-1 in Phospholipid Micelles Pharm Res. 28:662-672, 2011. DOI

Cesur H, Rubinstein I, Pai A, Onyuksel H. Self-associated indisulam in phospholipid-based nanomicelles: a potential nanomedicine for cancer. Nanomedicine. 2009 Jun;5(2):178-83. Epub 2008 Dec 13. DOI

Onyuksel H, Jeon E, Rubinstein I. Nanomicellar paclitaxel increases cytotoxicity of multidrug resistant breast cancer cells. Cancer Letters. 2009 Feb 18;274(2):327-30. Epub 2008 Nov 20. DOI

Onyuksel H, Mohanty PS, Rubinstein I. VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: A novel targeted nanomedicine for breast cancer. Int J Pharm. 2009 Jan 5;365(1-2):157-61. Epub 2008 Aug 27. DOI

Lu E, Franzblau S, Onyuksel H, Popescu C. Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion. J Microencapsul. 2008 Aug 21:1-9. [Epub ahead of print]. DOI

Lim SB, Rubinstein I, Onyuksel H. Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles. Int J Pharm. 2008 May 22;356(1-2):345-50. Epub 2008 Jan 17. DOI

Rubinstein I, Soos I, Onyuksel H. Intracellular delivery of VIP-grafted sterically stabilized phospholipid mixed nanomicelles in human breast cancer cells. Chem Biol Interact. 2008 Jan 30;171(2):190-4. Epub 2007 Apr 6. DOI

Wang H, Onyuksel H, Gulati A, Rubinstein I. Self-association of endothelin-1 with sterically stabilized phospholipid nanomicelles amplifies its hemodynamic effects in Rats. J Biomed Nanotechnol. 2007;3:270 DOI

Koo O, Rubinstein I, Onyuksel H. Camptothecin in sterically stabilized phospholipid nano-micelles: A novel solvent pH change solubilization method. J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):2996-3000.

Onyuksel H, Séjourné F, Suzuki H, Rubinstein I. Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension. Peptides. 2006 Sep;27(9):2271-5. Epub 2006 Apr 18. DOI

Rubinstein I, Ikezaki H, Onyuksel H. Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in hypertensive hamsters. Int J Pharm. 2006 Jun 19;316(1-2):144-7. Epub 2006 Mar 6. DOI

Koo OM, Rubinstein I, Onyuksel H. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomedicine. 2005 Sep;1(3):193-212. DOI

Arleth L, Ashok B, Onyuksel H, Thiyagarajan P, Jacob J, Hjelm RP. Detailed structure of hairy mixed micelles formed by phosphatidylcholine and PEGylated phospholipids in aqueous media. Langmuir. 2005;21(8):3279-90. DOI

Koo OM, Rubinstein I, Onyuksel H. Camptothecin in Sterically Stabilized Phospholipid Micelles: A Novel Nanomedicine. J. Nanomedicine. 2005 Sep;1:77-84. DOI