Department of Biopharmaceutical Sciences

College of Pharmacy

Hayat Onyuksel, Ph.D.

Hayat Onyuksel, Ph.D.

Acting Assistant Head, Graduate Studies

Professor, Pharmaceutics and Bioengineering

Contact Information
833 South Wood Street
358 Pharm, MC 865
Chicago, IL 60612-7231
Office: (312) 996-2097
Fax: (312) 996-0098

Publications (2005-2009)
Formulation and Delivery of Peptide and Protein Drugs Using Lipi-Based Carrier Systems

Banerjee A,Onyuksel H. A Novel Peptide Nanomedicine for Treatment of Pancreatogenic Diabetes. Nanomedicine: Nanotechnology, Biology, and Medicine, In press, 2013.

Sethi V., Rubinstein I., Kuzmis A., Artwohl J., Kastrissios H., and Onyuksel H. Novel, Biocompatible, Disease Modifying Nanomedicine of VIP for Rheumatoid Arthritis. Molecular Pharmaceutics, 10: 728-738, 2013 .

Lim S.B, Banerjee A,Onyuksel H. Improvement of drug safety by the use of Lipid-based Nanocarriers. J.Control.Release 163: 34-45, 2012

Banerjee A, Onyuksel H. Peptide Delivery using Phospholipid Micelles. WIRE's Nanomed Nanobiotechnol 4(5):562-74, 2012

Banerjee A,Onyuksel H. Human Pancreatic Polypeptide in a Phospholipid Micellar Formulation. Pharm Res 29: 1698-1711, 2012.

Williams R.L, Lim S.B, Onyuksel H, Marucha P.T. Sterically Stabilized Phospholipid Micelles Reduce Activity of a Candidate Antimicrobial Wound Healing Adjunct. Int J Pept Res Ther. 18: 195-203, 2012.

Kuzmis A, Lim SB, Desai E, Jeon E, Lee BS, Rubinstein I, Onyuksel H. Micellar Nanomedicine of Human Neuropeptide Y. Nanomedicine. 2011 Aug; 7(4): 464-71. Epub 2011 Jan 25. DOI

Brandenburg K.S, Rubinstein I, Sadikot R.T, Onyuksel H. Polymyxin B Self-associated with Phospholipid Nanomicelles. Pharm. Dev. and Tech.,17: 654–660, 2012 DOI

Lim SB, Rubinstein I, Onyuksel H. Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles. Int J Pharm. 2008 May 22;356(1-2):345-50. Epub 2008 Jan 17. DOI

Wang H, Onyuksel H, Gulati A, Rubinstein I. Self-association of endothelin-1 with sterically stabilized phospholipid nanomicelles amplifies its hemodynamic effects in Rats. J Biomed Nanotechnol. 2007;3:270 DOI

Onyuksel H, Séjourné F, Suzuki H, Rubinstein I. Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension. Peptides. 2006 Sep;27(9):2271-5. Epub 2006 Apr 18. DOI

Rubinstein I, Ikezaki H, Onyuksel H. Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in hypertensive hamsters. Int J Pharm. 2006 Jun 19;316(1-2):144-7. Epub 2006 Mar 6. DOI

Lu J, Jeon E, Lee BS, Onyuksel H, Wang ZJ. Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes. J Control Release. 2006;110(3):505-513. DOI

Sethi V, Onyuksel H, Rubinstein I. Liposomal vasoactive intestinal peptide. Methods in Enzymology. 2005;391:377-95. DOI

Rubinstein I, Ashok B, Tsueshita T, Onyuksel H. All D-VIP mitigates vasodilation elicited by L-VIP, micellar L-VIP and micellar PACAP1-38, but not PACAP1-38, in vivo. Peptides. 2005 Mar;26(3):509-15. DOI