Department of Biopharmaceutical Sciences

College of Pharmacy

Maria V. Barbolina, Ph.D.

Maria Barbolina, Ph.D.

Assistant Professor, Pharmacology

Contact Information
833 South Wood Street
453 PHARM, MC 865
Chicago, IL 60612-7231
Office: (312) 335-0670
Fax: (312) 996-0098


Postdoctoral - Northwestern University - 2008
Postdoctoral - State University of New York at Buffalo - 2004
Ph.D. - Russian Academy of Sciences - 2001
B.S. - Lomonosov Moscow State Academy of Fine Chemical Technology - 1996

Research Interests

Microenvironmental Regulation
of Ovarian Carcinoma Metastasis

(Related Publications)

Signal Transduction Pathways
(Related Publications)

Mechanisms of Chemoresistance

Publications (2007-2012)

Barbolina MV, Moss NM, Westfall SD, Liu Y, Burkhalter RJ, Marga F, Forgacs G, Hudson LG, Stack MS Microenvironmental Regulation of Ovarian Cancer Metastasis. Chapter 15 In: Ovarian Cancer (Editors Stack and Fishman), 2009.

Moss N., Barbolina MV, Liu Y, Lin Y, Munshi HG, Stack MS Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Regulates Ovarian Carcinoma Cell Detachment and Multi-cellular Aggregate Formation:  A Potential Role in Intra-Peritoneal Metastatic Dissemination. Cancer Research. 2009 September 1; 69(17); 7121-7129.

Cahill M, Xie Z, Day M, Barbolina MV, Miler C, Weiss C, Radulovic J, Sweatt JD, Disterhoft JF, Surmeier JD, Penzes P. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proceedings of the National Academy of Sciences USA. 2009 August 4; 106(31); 13058-63.

Woolfrey K, Srivastava D, Photowala H, Yamashita M, Barbolina MV, Cahill ME, Xie Z, Jones KA, Quilliam LA, Prakriya M, Penzes P. Epac2 promotes synapse dynamic remodeling and depression, and its disease-associated variants affect spine morphology. Nature Neuroscience. 2009 October; 12(10); 1275-1284.

Barbolina MV, Adley BP, Kelly DL, Shepard J, Fought AJ, Scholtens D, Penzes P, Shea LD, Stack MS, Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion, Int J Cancer. 2009 Aug 15;125(4):816-25. DOI

Barbolina MV, Adley BP, Kelly DL, Fought AJ, Scholtens DM, Shea LD, Stack MS, Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma, Lab Invest. 2008 Jun;88(6):602-14. Epub 2008 Mar 24.  DOI

Barbolina MV, Adley BP, Shea LD, Stack MS. Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion. Cancer, 2008, 112(7):1632-41. DOI

Barbolina MV, Stack MS. Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol 2008;19 (1):24-33. DOI

Barbolina MV, Kristoforov R, Manfredo A, Chen Y, Gollnick P. The rate of TRAP binding to RNA is crucial for transcription attenuation control of the B. subtilis trp operon. J Mol Biol 2007;370 (5):925-38. DOI

Barbolina MV, Adley BP, Ariztia EV, Liu Y, Stack MS. Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. J Biol Chem 2007;282 (7):4924-31. DOI

Barbolina MV, Li X, Gollnick P. Bacillus subtilis TRAP binds to its RNA target by a 5' to 3' directional mechanism. J Mol Biol 2005;345 (4):667-79. DOI