Department of Biopharmaceutical Sciences

College of Pharmacy
masthead

Xiaolong He, Ph.D.

Xiaolong He, Ph.D.

Assistant Professor, Pharmacology

Contact Information
University of Illinois College of Pharmacy at Rockford
1601 Parkview Avenue, Room N308
Rockford, Illinois 61107
Office: (815) 395-5929
Email: xiaohe@uic.edu


Education

Postdoctoral – Children's Memorial Institute for Education and Research, Children's memorial Hospital, Chicago, IL
Postdoctoral – Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX
Ph.D. – Second Military Medical University, Shanghai, China
M.S. – Fourth Military Medical University, Xi'an, Shanxi Province, China
B.S. in Medicine – First Military Medical University (currently Southern Medical University), Guangzhou, Guangdong Province, China




Research Interests

  • Alternative splicing and splicing factors in tumorigenesis
  • Model systems for monitoring of alternative splicing
  • Mechanisms of gene mutations and development of drug resistance
 



Publications


He X , Arslan AD, Ho TT, Yuan C, Stampfer MR, Beck WT. Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties. Oncogenesis. 2014 Jan 13;3:e84. doi: 10.1038/oncsis.2013.47.

Arslan AD, He X, Wang M, Rumschlag-Booms E, Rong L, Beck WT. A high-throughput assay to identify small-molecule modulators of alternative pre-mRNA splicing. J Biomol Screen. 2013 Feb;18(2):180-90.

Cho S, Lu M, He X, Ee PL, Bhat U, Schneider E, Miele L, Beck WT. Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proc Natl Acad Sci USA. 2011 Dec 20; 108(51):20778-83.

Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT. Novel Regulation of Nuclear Factor-YB by miR-485-3p Affects the Expression of DNA Topoisomerase IIα and Drug Responsiveness. Mol Pharmacol. 2011 Apr; 79(4):735-41.

He X , Arsalan AD, Pool MD, Ho TT, Darcy KM, Coon JS, Beck WT. Knockdown of Splicing Factor SRp20 Causes Apoptosis in Ovarian Cancer Cells and its Expression is Associated with Malignancy of Epithelial Ovarian Cancer. Oncogene. 2011 Jan 20; 30(3):356-65.

He X , Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene. 2007;26:4961-68. DOI

Ebert AD, Chen F, He X, Cryns VL, Bohn MC. Atetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. Exp Neurol. 2005 Feb;191 Suppl 1:S80-94. DOI

Ee PL, He X, Ross DD, Beck WT. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther. 2004 Dec;3(12):1577-83. DOI

He X , Ee PL, Coon JS, Beck WT. Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. Clin Cancer Res. 2004;10(14):4652-60. DOI

Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD, Beck WT. Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res. 2004;64(4):1247-51. DOI

Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in Tlr4 Gene. Science. 1998 Dec 11; 282(5396):2085-8.
(This paper helped the senior author, Dr. Bruce Beutler, win The Nobel Prize in Physiology or Medicine in 2011)

Poltorak A, Smirnova I, He X, Liu, MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, Vogel SN, Beutler B. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sept; 24(3):340-55.