Xiaolong He, Ph.D.
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Assistant Professor, Pharmacology Contact Information University of Illinois College of Pharmacy at Rockford 1601 Parkview Avenue, Room N308 Rockford, Illinois 61107 Office: (815) 395-5929 Email: xiaohe@uic.edu |
Education
Ph.D. - Second Military Medical University, Shanghai, China
Research Interests
| Alternative splicing and splicing factors in tumorgenesis (Related Publications) Biomarker development for early detection of ovarian cancer (Related Publications) Molecular pharmacology and genetics of anticancer drug action and tumor cell drug resistance (Related Publications) |
Publications (2007-2012)
Cho S, Lu M, He X, Ee PL, Bhat U, Schneider E, Miele L, Beck WT. Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proc Natl Acad Sci USA. 2011 Dec 20; 108(51):20778-83.
Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT. Novel Regulation of Nuclear Factor-YB by miR-485-3p Affects the Expression of DNA Topoisomerase IIα and Drug Responsiveness. Mol Pharmacol. 2011 Apr; 79(4):735-41.
He X, Arsalan AD, Pool MD, Ho TT, Darcy KM, Coon JS, Beck WT. Knockdown of Splicing Factor SRp20 Causes Apoptosis in Ovarian Cancer Cells and its Expression is Associated with Malignancy of Epithelial Ovarian Cancer. Oncogene. 2011 Jan 20; 30(3):356-65.
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in Tlr4 Gene. Science. 1998 Dec 11; 282(5396):2085-8.
(This paper helped the senior author, Dr. Bruce Beutler, win The Nobel Prize in Physiology or Medicine in 2011)
Poltorak A, Smirnova I, He X, Liu, MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, Vogel SN, Beutler B. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sept; 24(3):340-55.
He X, Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene. 2007;26:4961-68. DOI
Ebert AD, Chen F, He X, Cryns VL, Bohn MC. Atetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. Exp Neurol. 2005 Feb;191 Suppl 1:S80-94. DOI
Ee PL, He X, Ross DD, Beck WT. Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference. Mol Cancer Ther. 2004 Dec;3(12):1577-83. DOI
He X, Ee PL, Coon JS, Beck WT. Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. Clin Cancer Res. 2004;10(14):4652-60. DOI
Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD, Beck WT. Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res. 2004;64(4):1247-51. DOI